ID A0A3Q2EA69_CYPVA Unreviewed; 1199 AA.
AC A0A3Q2EA69;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Myelin transcription factor 1 {ECO:0000313|Ensembl:ENSCVAP00000028539.1};
GN Name=MYT1 {ECO:0000313|Ensembl:ENSCVAP00000028539.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000028539.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000028539.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MYT1 family.
CC {ECO:0000256|ARBA:ARBA00010194}.
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DR AlphaFoldDB; A0A3Q2EA69; -.
DR Ensembl; ENSCVAT00000030629.1; ENSCVAP00000028539.1; ENSCVAG00000015820.1.
DR GeneTree; ENSGT00940000156364; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 4.10.320.30; -; 7.
DR InterPro; IPR013681; Myelin_TF.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR10816:SF10; MYELIN TRANSCRIPTION FACTOR 1; 1.
DR PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR Pfam; PF08474; MYT1; 1.
DR Pfam; PF01530; zf-C2HC; 7.
DR SUPFAM; SSF103637; CCHHC domain; 7.
DR PROSITE; PS51802; ZF_CCHHC; 6.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT DOMAIN 639..888
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 29..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1070..1132
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..165
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..248
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..300
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..854
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1199 AA; 132680 MW; 2DB06AE23AFBCD00 CRC64;
MMSVEGDDKR TRTRSKGIRV PIELIGQELS CPTPGCNGSG HISGRYSRHR SLLACPIARK
RRLEEAEQEQ EQETGKPSSK RKSHPLKLAL DEGFSAESDT SSEAEDEAAK DGEKGDKEGE
KDAGREEMAP EHPEQDGKGL MNGQEEEEEE EEEEEMSAGD EEQECLIVEP ELRAAPPAAE
VSPPPSQSAE EVADSLLHLG QVSNSHTHGV ALQQIEDVSA AAEGGEEEKD EQEEAMHEGE
EEEEEAQRTL EESSALQNDG RTVEEEEGEH VNMSNHVSHS QQIKGEEEEE EEEEEEEMVV
SVQQTQETPA EDEGDDEKDE EEHSSFLSIS DVPTAVQTIT STAAAQGTHI KTENHRLLED
YGSNRYGSLP DFKSSPPLSS HTASPLHDYF SIPRGDNFKI HKASASPDVI EVRSDKSEEK
DFDDLDGDDE RDDDDSLSQR STVTDESEMF DMTRGNLGLL EQAIALKAEQ VKPAGPRELL
RAPDLHHQRY FTIEDRPKHL DIIRKTYFSK ERPEKRENKC PTPGCDGTGH VTGLYPHHRS
LSGCPHKDRI PPEILAMHEN VLKCPTPGCT GQGHVNSNRN THRSLSGCPI AAAEKLSKTH
DKQHLSQLGG EHLKGSPNDR VLRPMCFVKQ LEVPQYGNYR PNMAPSTPRA NLAKELEKYS
KVSFDYASFD AQVFGKRTLA PKMTTSETSP KAFKTKPSFP ESSSPTLSLH AYGKSSSLPY
DYSHDAEAAH MAATAILNLS TRCWEKPENL SIKPQSKEMD IEVDENGTLD LSMKKPIKRE
GSVSGTSPGV RSPDPSSSSS SSSFHHGGNS GMTSPNLQTY KQEEWEGPLD FTKPNRQREE
EADEMEHTGH SYVSSDQEDC DGLQDCLEDR KYPGEVTTPS FKVKFQPKDS KKELLSCPTP
GCDGSGHITG NYASHRRCPT PGCDGSGHIT GNYASHRSLS GCPRAKKSGI KTPTKDNQED
SELLKCPVPG CDSLGHISGK YATHRSAYGC PLAARRQKEG LLNGMPFNWK AFKTEGPTCP
TPGCDGSGHA NGSFLTHRSL SGCPRALYAK KKAKFPSDDY LSTKFRATDV LDNDEEIKQL
NREINDLNES NNEMEADMVN LQTQISSMEK NLKSIEHENK MIEEQNEALF MELSGLSRAL
IRSLANIHLP HMQEPITEQN FDNYISTLTD MYTNKECFQS PENKALLESI NKAVKGIKV
//
