ID   A0A3Q2EBQ2_CYPVA        Unreviewed;       639 AA.
AC   A0A3Q2EBQ2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Interleukin-1 receptor-like 2 {ECO:0000313|Ensembl:ENSCVAP00000029114.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000029114.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000029114.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC       {ECO:0000256|ARBA:ARBA00009752}.
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DR   AlphaFoldDB; A0A3Q2EBQ2; -.
DR   STRING; 28743.ENSCVAP00000029114; -.
DR   Ensembl; ENSCVAT00000030962.1; ENSCVAP00000029114.1; ENSCVAG00000016657.1.
DR   GeneTree; ENSGT01090000259985; -.
DR   OMA; CHLNFPQ; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11890:SF45; INTERLEUKIN-1 RECEPTOR TYPE 1-LIKE; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01536; INTRLKN1R12F.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00409; IG; 3.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..639
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018537444"
FT   TRANSMEM        350..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          148..228
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          399..621
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          486..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   639 AA;  72472 MW;  9E74C52BF14C2B2C CRC64;
     MGLLLFLWIL EIGAGLAQAE FIMKEKCTNY ELQFERVFSV PGDVAMLNST LLSPDVFNFT
     TTPFNITWYS TKSGQEMRNV TGQVLVTRET LWFLNTTMDD DGDYVTVLRT PAQCYMQSTK
     LVVNMPIDGE CGRPLKAYQV LTKDLSDTLH CPLRDYMDKL DSYGISSSVT WYKGCDPILD
     EPGRHTFRDR NKLTIDRVEN ENGGTYTCTL MFTLDGVNGS VSETIEVTVR DSYFLLPEIH
     EPGNKIVKAV KGSNLTQRCL VFIPGVGMPF VDAFWFVNYT FIPNKPSERI HMSEKRLWTQ
     DEPKGVWLER LLLFSELREE DFHLNYTCRA YSSRGFPEGY FTLLSTDPNI ILPIGLVAGG
     VTVLFIITVA VYYAFKIDIV LWFRRACPVV YANKDLDGKL YDAYVACPNP GALGFNEEVE
     KFALQILPEV LEQACGYKLF IAGRDCQPGQ AIMDSVDENL QASRRVLLLY TASTFKRNTS
     SSSNNNNITK ISEGGDEIES TTNESSCDVD VDDGDKVFLD TRQQLECVVA MYKALLEGSI
     KVVLVELEEI SPAQLALFPE SVRHLRKKQG AVCWWKALQT RQRWRVCSNL RKDEESGEKV
     SKVSPSLSPS SRFWKEIRYH MPVRGKRVVY PEKTALLNL
//