ID   A0A3Q2ED53_CYPVA        Unreviewed;       274 AA.
AC   A0A3Q2ED53;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Homeobox protein {ECO:0000256|PIRNR:PIRNR037109};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000030438.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000030438.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC       {ECO:0000256|ARBA:ARBA00003263, ECO:0000256|PIRNR:PIRNR037109}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR037109, ECO:0000256|PROSITE-ProRule:PRU00108,
CC       ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC       {ECO:0000256|ARBA:ARBA00006317, ECO:0000256|PIRNR:PIRNR037109}.
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DR   RefSeq; XP_015231763.1; XM_015376277.1.
DR   AlphaFoldDB; A0A3Q2ED53; -.
DR   STRING; 28743.ENSCVAP00000030438; -.
DR   Ensembl; ENSCVAT00000024345.1; ENSCVAP00000030438.1; ENSCVAG00000018964.1.
DR   GeneID; 107085752; -.
DR   KEGG; cvg:107085752; -.
DR   CTD; 30350; -.
DR   GeneTree; ENSGT00940000161503; -.
DR   OMA; MRSWMEP; -.
DR   OrthoDB; 728401at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR006711; Hox9_activation_N.
DR   InterPro; IPR017112; HXA9/HXB9/HXC9.
DR   PANTHER; PTHR45970; AGAP004664-PA; 1.
DR   PANTHER; PTHR45970:SF4; HOMEOBOX PROTEIN HOX-D9; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF04617; Hox9_act; 1.
DR   PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|PIRNR:PIRNR037109};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037109};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037109};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR037109};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR037109}.
FT   DOMAIN          204..264
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        206..265
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          117..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   274 AA;  31031 MW;  31796DE2290BB611 CRC64;
     MSSSGALSNC YVDAVMGQEP EELYGARFIQ PQHTVTPRPP PGAGDSADFS SCSFTPKSAV
     FSPSWTSMHP QGLYHPYVHH HHHHQSHLPA SDSRYVGMRS WMDPISNHVS FAGFHSSGSR
     PYGTKPELPL PTKPAGCEPL EETETVPGAE ARPPAAEFSC GSAECREKPS REQSGSEASS
     HGEPKDEKQQ LDPNNPAANW IHARSTRKKR CPYTKYQTLE LEKEFLYNMY LTRDRRYEVA
     RILSLTERQV KIWFQNRRMK MKKMNRERSG KEII
//