ID A0A3Q2EE34_CYPVA Unreviewed; 2672 AA.
AC A0A3Q2EE34;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=ITPR1 {ECO:0000313|Ensembl:ENSCVAP00000030783.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000030783.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000030783.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR STRING; 28743.ENSCVAP00000030783; -.
DR Ensembl; ENSCVAT00000024989.1; ENSCVAP00000030783.1; ENSCVAG00000019702.1.
DR GeneTree; ENSGT00940000155071; -.
DR OMA; DKSQDEG; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF2; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2209..2231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2243..2261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2289..2307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2327..2354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2375..2397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2493..2516
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 112..166
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 231..287
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 364..420
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 1114..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1682..1710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1804..1823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1861..1883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2064..2083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2649..2672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1682..1702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1807..1823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2672 AA; 304511 MW; 23795C95A7638956 CRC64;
MSDKMSSFLH IGDICSLYAE GSTSGFISTL GLVDDRCVVQ PDAGDLNNPP KKFRDCLFKL
CPMNRYSAQK QFWKAAKPGG NSTTDTVLLN KLHHAADLEK KQNESENRKL LGTVIQYGNV
IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDSAGNEGSW FYIQPFYKLR SLGDSVVIGD
KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKV VLFMKWSDNL ETILKGGDVV
RLFHAEQEKF LTCDDHRKKQ YVFLRTTGRQ SATSATSSKA LWEVEVVHHD PCRGGAGYWN
SLFRFKHLAT GCYLAAELDA DNEALRGRLR APQEKIMYTL VPVPDGMDVS SIFELDPTTL
RGGDSMVPRS SYVRLRHLCT NTWVHSTVIP IDKEEEKPVM LRIGTSAIKE DKEAFAIVPV
PPSEVRDLDF ANDASKVLAS IAGKLEKGTI TQNERRFVTK LLEDLVFFVV DIPNSGQDVL
EIMVNKPNRE RQKLMREQNI LKQIFKLLQA PFTDSGDGPM LRLEELGDQR HAPFRHICRL
CYRVLRHSQQ DYRKNQEYIA KQFRFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI
DTFVTLVRKN REPRFLDYLS DLCVSMHKSI PVTQELICNA VLDGTNADIL IETKLVLSRF
EIESAINEEA PVEAEDVEEV WLFWKDNCKE NRSKSVRELA QDAKEGQKED QEVVSYYRCQ
LNLFARMCLD RQYLAINKIS GQLDVDLILR CMSDEDLPFD LRASFCRLML HMHVDRDPQE
QVTPVKYARL WSEIPSKIAI DDYDNDGTTR DEIKERFSLT MDFVETYLRE VVSQNIPFSD
KEKNKLTFEV VNLARNLIYF GFYNFSDLLR LTKILLNILD CVHVSTVFPI NKIEKGDESK
GGSNVMKSIH GVGELMTQVV LRGGGLLPTT PSHQPEGDVV KTQTEPERED IMVMDTKLKI
IEILQFILNV RLDYRISCLL CIFKREFDEN NPQGDNAVNP NGGNLDFENI EEQAEGIFGG
SEENTPLDLD DHGGRTFLRV LLHLTMHDYP PLVSGALHLL FRHFSQRQEV LMAFKQVQLL
VTSQDVENYK QIKSDLDQLR SIVEKSELWV YKRQGEDGMD GDGPAESDNK KKKSTESTSS
YNYRVVKEIL VRLSKLCVQE VASGKKSKKQ QQRLLRNMGA HSVVLELLQI PYEKGEDVRM
QDIMKLAHEF LQNFCAGNQQ NQTLLHKHIN LFLNPGILEA VTMQHIFMNN SQLCNEINER
VVQHFVHCTE THGRHVQYLK FLQTIVKADN KFIKKCQDIV MAELVNSGED VLVFYNDRAS
FQTLVQMMRS ERDRLDENSP LMYHIHLVEL LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT
HEDCIPEVKI AYINFLNHCY VDTEVEMKEI YTSNHMWKLF ENFLVDICRV CNNTSDRKHA
DTTLERYVTE TVMSIVTCFF SSPFSDQSTS LQTRQPVFVQ LLQGVFRVYH CSWLSPAQKH
SVEGCIKVLS DVAKSRAIAI PVDLDSQVNN LFVKPNNVVQ KTLLSWKQSA KNTSRRESSL
SASKDYRNII EKLQDIVSAL EDRLRPLVQA ELSVLVDVLH RPELLFPENT DARKKCESGG
FISKLIKHTK QLLEENEERL CIKVLQTLRE MMTKDRGYGV KGEALRQILV NRYYGNVKSG
QRRDSLTSYS NGPLTAGAQG KSPTRDSGIG GRGELSLAEV QCHLDKEGAS DLVIDLIMNA
TSDRIFQESI LLAIALLEGG NTVIQRSFYN RLTGDNKSEK FFKVFYERMK LAQQEIKATV
TVNTSDLGSK KKEEEPPDKD MPMRKKVKDV PVVAMVTEEV KEQLVEASAV TKKAFTTYRR
EAEAEEHQAA ADGTPVQTAD KGQDEGEMSV IITIMQPILR LMQLLCENHN RDLQNFLRNQ
NNKNNYNLVC ETLQFLDCIC GSTTGGLGLL GLYINEKNVG LINQTVESLT EYCQGPCHEN
QNCIATHECN GIDIIIALIL NDINPLGKKR MDLVLELKNN ASKLLLAIME SRHDSENAER
ILYNMRPKEL VEVIKKAYMQ GEIEVEEPEE GEDEEEEHSA SPRNVGHNIY ILAHQLARHN
KELQAMLKPG GTYGEGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPNIC EFLTQESKLR
VYYTTERDEQ GSKINDFFLR SEDLFNEMNW QKKLRAQPIL YWCSRNMSFW SSISFNLAVL
MNLLVAFFYP LEGVRGGTLE PHLSALLWVA MLVSLAIVIV LPQPHGIRAL IASTILRLIF
SVGLEPTLLL LGGFNLCNKV IFLMSFVGNR GTFTRGYKAM IMDVEFLYHL LYLIICSLGV
FVHVFFYSLL LFDLVYREET LLNVIKSVTR NGRSIVLTAV LALILVYLFS IVGYIFFKDD
FILAVDRIPN NTLGMLNSLL FSGGVCQKEN GENCSTEAPS VVIEDKERTC DSLLMCIVTV
LSHGLRSGGG VGDVLRKPSK EEPLFAARVI YDLLFFFMVI IIVLNLIFGV IIDTFADLRS
EKQKKEEILK TTCFICGLER DKFDNKTVTF EEHIKVEHNM WHYLFFIVLV KVKDSTEFTG
PESYVAEMIR EHNLDWFPRM RAMSLVSSDA DGEQNEIRSL QEKLESTMKL VTNLSGQLTE
LKEQMTEQRK QKQRIGLLGH PQHMNVNPQQ PA
//
