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Database: UniProt
Entry: A0A3Q2EFU3_CYPVA
LinkDB: A0A3Q2EFU3_CYPVA
Original site: A0A3Q2EFU3_CYPVA 
ID   A0A3Q2EFU3_CYPVA        Unreviewed;       320 AA.
AC   A0A3Q2EFU3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Elongation of very long chain fatty acids protein 4 {ECO:0000256|HAMAP-Rule:MF_03204};
DE            EC=2.3.1.199 {ECO:0000256|HAMAP-Rule:MF_03204};
DE   AltName: Full=3-keto acyl-CoA synthase ELOVL4 {ECO:0000256|HAMAP-Rule:MF_03204};
DE   AltName: Full=ELOVL fatty acid elongase 4 {ECO:0000256|HAMAP-Rule:MF_03204};
DE            Short=ELOVL FA elongase 4 {ECO:0000256|HAMAP-Rule:MF_03204};
DE   AltName: Full=Very long chain 3-ketoacyl-CoA synthase 4 {ECO:0000256|HAMAP-Rule:MF_03204};
DE   AltName: Full=Very long chain 3-oxoacyl-CoA synthase 4 {ECO:0000256|HAMAP-Rule:MF_03204};
GN   Name=ELOVL4 {ECO:0000256|HAMAP-Rule:MF_03204};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000031388.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000031388.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the first and rate-limiting reaction of the four
CC       reactions that constitute the long-chain fatty acids elongation cycle.
CC       This endoplasmic reticulum-bound enzymatic process allows the addition
CC       of 2 carbons to the chain of long- and very long-chain fatty acids
CC       (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0
CC       and C26:0 acyl-CoAs. May participate to the production of saturated and
CC       monounsaturated VLCFAs of different chain lengths that are involved in
CC       multiple biological processes as precursors of membrane lipids and
CC       lipid mediators. {ECO:0000256|HAMAP-Rule:MF_03204}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC         chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC         EC=2.3.1.199; Evidence={ECO:0000256|HAMAP-Rule:MF_03204,
CC         ECO:0000256|RuleBase:RU361115};
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000256|HAMAP-
CC       Rule:MF_03204}.
CC   -!- SUBUNIT: Oligomer. {ECO:0000256|HAMAP-Rule:MF_03204}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|HAMAP-Rule:MF_03204}; Multi-pass membrane protein
CC       {ECO:0000256|HAMAP-Rule:MF_03204}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ELO family. ELOVL4 subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_03204}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_03204}.
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DR   RefSeq; XP_015238013.1; XM_015382527.1.
DR   AlphaFoldDB; A0A3Q2EFU3; -.
DR   Ensembl; ENSCVAT00000026304.1; ENSCVAP00000031388.1; ENSCVAG00000020620.1.
DR   GeneID; 107089631; -.
DR   KEGG; cvg:107089631; -.
DR   CTD; 393769; -.
DR   GeneTree; ENSGT01050000244838; -.
DR   OMA; WTYFTST; -.
DR   OrthoDB; 168669at2759; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009922; F:fatty acid elongase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0034626; P:fatty acid elongation, polyunsaturated fatty acid; IEA:UniProtKB-UniRule.
DR   GO; GO:0019367; P:fatty acid elongation, saturated fatty acid; IEA:UniProtKB-UniRule.
DR   GO; GO:0035338; P:long-chain fatty-acyl-CoA biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0042761; P:very long-chain fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03204; VLCF_elongase_4; 1.
DR   InterPro; IPR030457; ELO_CS.
DR   InterPro; IPR002076; ELO_fam.
DR   InterPro; IPR033678; ELOVL4.
DR   PANTHER; PTHR11157:SF137; ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4; 1.
DR   PANTHER; PTHR11157; FATTY ACID ACYL TRANSFERASE-RELATED; 1.
DR   Pfam; PF01151; ELO; 1.
DR   PROSITE; PS01188; ELO; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|HAMAP-Rule:MF_03204};
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160, ECO:0000256|HAMAP-
KW   Rule:MF_03204};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832, ECO:0000256|HAMAP-
KW   Rule:MF_03204};
KW   Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_03204,
KW   ECO:0000256|RuleBase:RU361115};
KW   Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_03204,
KW   ECO:0000256|RuleBase:RU361115};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_03204};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_03204};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_03204};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_03204}.
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03204,
FT                   ECO:0000256|RuleBase:RU361115"
FT   TRANSMEM        68..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03204,
FT                   ECO:0000256|RuleBase:RU361115"
FT   TRANSMEM        117..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03204,
FT                   ECO:0000256|RuleBase:RU361115"
FT   TRANSMEM        148..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03204,
FT                   ECO:0000256|RuleBase:RU361115"
FT   TRANSMEM        172..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03204,
FT                   ECO:0000256|RuleBase:RU361115"
FT   TRANSMEM        206..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03204,
FT                   ECO:0000256|RuleBase:RU361115"
FT   TRANSMEM        235..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03204,
FT                   ECO:0000256|RuleBase:RU361115"
FT   REGION          266..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   320 AA;  37838 MW;  03F9593998258B6A CRC64;
     MEIVTHLIND TIEFYKWTLT IADKRVEKWP LMDNPLPTLA ISTSYLLFLW LGPKYMKNRE
     PFQLRKTLIV YNFSMVFLNF FIFKELFMAA RAAQYSYICQ PVDYSDDPNE VRVAGALWWY
     FISKGIEYLD TVFFILRKKF NQVTFLHVYH HCTMFTLWWI GIKWVAGGQS FFGAHMNALI
     HVLMYLYYGL ASCGPRIQKY LWWKKYLTII QMVQFHVTIG HTALSLYVNC DFPHWMHYSL
     ICYAITFIVL FGNFYYQTYR RQQPTRRDAS SSTKAGKHVY NGNLNGLSRA ANGTPLVTSK
     EEKPQENSGR RKRKGRAKRD
//
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