ID A0A3Q2EG93_CYPVA Unreviewed; 696 AA.
AC A0A3Q2EG93;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Pro-neuregulin-2, membrane-bound isoform-like {ECO:0000313|Ensembl:ENSCVAP00000031307.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000031307.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000031307.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the neuregulin family.
CC {ECO:0000256|ARBA:ARBA00008216}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q2EG93; -.
DR STRING; 28743.ENSCVAP00000031307; -.
DR Ensembl; ENSCVAT00000026040.1; ENSCVAP00000031307.1; ENSCVAG00000000539.1.
DR GeneTree; ENSGT00940000158778; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR040180; Neuregulin.
DR InterPro; IPR002154; Neuregulin_C.
DR PANTHER; PTHR11100; HEREGULIN-NEUREGULIN FAMILY MEMBER; 1.
DR PANTHER; PTHR11100:SF20; PRO-NEUREGULIN-2, MEMBRANE-BOUND ISOFORM; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF02158; Neuregulin; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 302..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 141..228
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 243..284
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 394..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..551
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..616
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..633
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 255..272
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 274..283
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 696 AA; 77032 MW; 1F5CAAF702E6A394 CRC64;
MRLDPVHFSM LVIGVSFACY APSLNSLQDQ AYRSAVVIEG EVRSSPENGS SSEPYRVNVR
VLDVWPVNSG GLEREQLVTV GDFGSEAPCT TVEKDHRYIF FMDPTADPLV FKASYAPVDA
SEPELKKDVE RVLCGDCASA PKLRPMQGQS LMEGEKMYLK CEASGTPSPS FRWYKDGHEL
QKGRDLKIKT NKKNSKVQIS RVRVEDSGNY TCVAENSLGQ ENVTSIITVQ IMTTTTPSPG
VSHARRCNDS EKAYCANGGD CYFIHGINQL SCKCPNDYSG DRCQNSVMAG FYKAELVYQR
RVLTITGICV ALLVVGIVCV VAYCKTKSQR RQMQNHLHQN QNQFVEQPNR MLANGPNHPG
PGPEEIPMVD YISKSVPTTE CVISHGAEGA GNYAGSRMST RSHHSTTASH ASRHEEQTWS
MERTESVNSD CQSGGLSSSV GTSKCSSPAC MARRAANYGC RDMSGMGMQY GDSYDSLRDS
PHSDRYVSAL TTPARLSPVE FHYPPLPPQV PTFQITSPNT SHALSLPPAA AAYHRDDDQP
FLYRQPRRPR RPYLTESTGS LPSSPYHLPD DEAYETTQEY ASSREPIRSR RRPRRNRLNG
HTSQRSAGFR DYSSQSFSQS EDEEEEDEDE DAHGESTPFL SMQNMNMDLP LSSSGYRSSS
GADTRTHRGL SRPGTRSNGQ SRGSQSQRSK ADNMPL
//
