ID A0A3Q2EH85_CYPVA Unreviewed; 717 AA.
AC A0A3Q2EH85;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=YTH domain containing 2 {ECO:0000313|Ensembl:ENSCVAP00000031756.1};
GN Name=YTHDC2 {ECO:0000313|Ensembl:ENSCVAP00000031756.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000031756.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000031756.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2EH85; -.
DR Ensembl; ENSCVAT00000026910.1; ENSCVAP00000031756.1; ENSCVAG00000021377.1.
DR GeneTree; ENSGT00940000155826; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..121
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 211..377
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REPEAT 489..521
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 594..717
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 153..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 81022 MW; 06E8D0D0DEF8BC96 CRC64;
MFRAVAVTFQ RIFEFIYIYF FSFLEYAIFT QIQQHSKETQ LEKDKQIKKY EKQSISYLEV
ILLAHVQEES CFRYGSEQLE FPSSFSSTER AFVHRLAQSL GYSSRSKGKG SSRFLTVRKK
ETSAKLQPSI CLDLSSSSAY FIRSLLQRFP PSKKERADLH PNAKSGNPLV TESTSGRLNN
GIPMVPKKRT PSVLDAFRRS LPVTEHQDEI VQLIRDHRVV LVLGETGSGK TTQIPQFLLD
DCSRYGKPCR IFCTQPRRLA TIAVAERVAA ERGESVGQTV GYHIRLESRV SPKTLLTFCT
SGVLLRTLMA GDGSLTTVTH VIVDEVHERD GLTDFLLTKL RDVLQKVPTL KLILSSAALD
IDLFLQYFGS CPVIRRKLRP HCVSMKLLKE TQQKRLNEWF EAAGSGAVGA TLTHMFPPGL
LDAGGCGDRE KESIQQSEKD PEQLKPWLLK EMDSCISSIF LHEDQDAFSQ LFNLILHERV
SVDYTHSETG STPLMASAAR GFLPEMQQLL SMGADINMRA CNGWTALDFA EHFQQTDAVD
LRESRTLEIE LTDSESTLIH CSPTELNSEA QELLRQYHHS FDDQQVDLDL IMTLLLNICT
NTNEGAVLIF LPGYDEIVTL RDRIFSDDRM STHYQVFTLH SDMQTLDQKR AMKPTPSGVR
KIILSTNIAE TSITIDDVVF VIDSGKVKEK SFDTLSRVSM LKSVWICKAS VLQRKGR
//
