ID   A0A3Q2EHX4_CYPVA        Unreviewed;       691 AA.
AC   A0A3Q2EHX4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Eukaryotic elongation factor 2 kinase {ECO:0000313|Ensembl:ENSCVAP00000032001.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000032001.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000032001.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2EHX4; -.
DR   Ensembl; ENSCVAT00000027382.1; ENSCVAP00000032001.1; ENSCVAG00000021788.1.
DR   GeneTree; ENSGT00940000157839; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR004166; a-kinase_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR45992:SF2; EUKARYOTIC ELONGATION FACTOR 2 KINASE; 1.
DR   PANTHER; PTHR45992; EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF81901; HCP-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          94..327
FT                   /note="Alpha-type protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS51158"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          430..449
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        434..449
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   691 AA;  77996 MW;  003E199B0BD27BBF CRC64;
     IMDDELMFSM EEEGSAQRPS SQRNGFKQRA SSLSDANASE DDDDEENFIS PILGESAKES
     GNYLKDFAYN RQLSNSLPKT NFLYRAAWIK AIEKARAMPD PWAQFHLEEI ETEPCIRYRY
     SAVTGEWAQD QIHIKMAAQK LSNFSHSSNW KSASNYVAKR YMETVDREVY FEDVRLQMEA
     KLWGEEYNRH RPPKQVDIMQ MCVVEMTNRP GKPVFHLEHY IEGKYIKYNS NSGFVRDDNI
     RLTPQPSIIS PFPPSGLQSL HGPSDPHREG NRFRRWESRY VSSLYSLMAT EIPQSDDIGV
     PGVRGMALFF HSHLCNKICK SMGLTPFDLS EPESSQLDCT NKLLKSAKTV LRGCEEVCGS
     PRVRTWSASR VPPLLSRLSD PSSADESASD VDSIPCSPLT LPFSPVVAPG SMGRSPSGTF
     LKLYYSESES GGDSGYPSER RSEGDPNDHI DGMTDEKWTF FHSSRAHVHR SSCVATEVER
     LNALMQKKIG QSILGKVHLA MVRYHEAGRF CEKDEQWDQD SAFFHLERAA LCGELEAIVA
     LGKCYLQLPH HVLPDMEVEV KPGFKYLLQA AEAGDRSSMI IVARAFDTGF NLSADRSQDW
     AEAIHWYDSA LNMMDYDEGG EFDGTQDEPR YLLLAREAEM YQEGGFNLTA DPQKAGDLFT
     EAAEAAIAAM KGRLANQYYM KAEEAWALVE E
//