ID   A0A3Q2EI11_CYPVA        Unreviewed;       449 AA.
AC   A0A3Q2EI11;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=tRNA (guanine(10)-N2)-methyltransferase homolog {ECO:0000256|ARBA:ARBA00013960};
DE   AltName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 homolog {ECO:0000256|ARBA:ARBA00032604};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000031469.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000031469.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC       tRNA methyltransferase complex that mediates the methylation of the
CC       guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC       {ECO:0000256|ARBA:ARBA00002425}.
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DR   AlphaFoldDB; A0A3Q2EI11; -.
DR   Ensembl; ENSCVAT00000032392.1; ENSCVAP00000031469.1; ENSCVAG00000020822.1.
DR   GeneTree; ENSGT00390000018131; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR   PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR   PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
DR   PROSITE; PS51627; SAM_MT_TRM11; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT   DOMAIN          179..309
FT                   /note="UPF0020"
FT                   /evidence="ECO:0000259|Pfam:PF01170"
FT   REGION          302..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..320
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   449 AA;  51240 MW;  06B2225DEC885303 CRC64;
     MAASNRSCLQ YLFHLAHDNL EFRLPVTLFS HIQMSSPFWC LEGLSVEDVC SVMDRSVCAK
     SAFELWGHGQ SHSELRTSLL SYPQEKMSPY MQKGSSYKIN VYTFNKTLLF EERIKKIDAM
     DYLPFQGTVN LKNPQFTFCL LEDYGTDPNN IPELPNYVYF GRLIADGQRE LIRSYSVKNR
     HFIGNTSMDA GLSFIMANHA MVKENDLVFD PFVGTGSLLV SCSHFGAYVC GTDIDYNTIH
     GKGRSSRKNQ KWRGPDENIR ANLRQYGTES MYVDVMVSDA SKPVWRNAAL FDAIITDPPY
     GIRESTRRTG SHKDTIKSPD ESHVPVSQAY HLSDIFTDLL NFSAHHLVLG GRLVYWLPVY
     RPEYCEEMVP LHPCLRLISN CEQMLSSHTS RRLITMEKIK EPEELDSLAH LSDPHFSGYQ
     KHNAFREKYF SGLNKRSGKD DTKADVSGK
//