ID A0A3Q2EIZ5_CYPVA Unreviewed; 1695 AA.
AC A0A3Q2EIZ5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=SH3 and multiple ankyrin repeat domains protein 1-like {ECO:0000313|Ensembl:ENSCVAP00000032588.1};
GN Name=SHANK1 {ECO:0000313|Ensembl:ENSCVAP00000032588.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000032588.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000032588.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density
CC {ECO:0000256|ARBA:ARBA00034105}.
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DR STRING; 28743.ENSCVAP00000032588; -.
DR Ensembl; ENSCVAT00000033113.1; ENSCVAP00000032588.1; ENSCVAG00000022791.1.
DR GeneTree; ENSGT00940000153561; -.
DR OMA; EEIHKAC; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09506; SAM_Shank1_2_3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24135:SF3; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT REPEAT 165..198
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 199..231
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 299..331
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 474..533
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 573..667
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1632..1695
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 380..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1544..1578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..856
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..959
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1193
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1303
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1695 AA; 186466 MW; 7A7C9F982B09E99D CRC64;
MVQKFGCRKT WIQQCQCDIQ PELYGSSLSK GLAIQSLTQC LQFDQDCTVW SAKQQIVCSL
GESLWDVYNY GLFQPAGEGR DAKFLEEERP LRDYARTFEK GVPYLEFRYK TRVYKQTNLD
EKALAKLTTK ASQKKFIEYV QTGAMEKMAK VLDKGLDPNF HDPDSGETPL SVAVQSGLSV
EGIRLLVLGG AHMDFRSRDG MTALHKAVRA HNHAGLLALL SLGASPDYKD RCGLTPLYHT
VLTGGETSCC ETLLYYRAKL GTRDENGWDE SHQACQNGFA QHLEHLLFYG ADTASQNASG
NTALHISALY NKESCVRVLL YRGANKEAKN KHGQTPFQVA VMSGHFELGE IIKNHKDTDI
VPFLESPKFV PRRKDSVHTL PLPSLQSHPL LRANSDNTMT QSDPLSLPNK AATNPNPGQV
LKGLGMCASV DLCDNMHSLC DLHAWSSVCL CRASAGAPSA GSGGGQMKRM YSAVPGRMYV
AIRSHSASGD RELSLNKGDK VKVLSVGEGG YWEGTARGRT GWFPSDCVQE VAPPSKEKET
RSEKAKRKLF RNVTVGAYDG TDGPSDYIIK EKTVLLQKKD NEGFGFVLRG AKAQTPIEEF
TPTPAFPALQ YLESVDEGGV AWRAGLRMGD FLIEVNGQNV VKVGHRQVVN MIRQGGNSLM
VKVVMVARNP ELEDTARKKA PQQTKRLTPP AIALRSKSMT SELEDMVCFT IKDSYKNVLH
NIWFKYQIVP FHYIQTYIYV VLFAFLFEMC SNTLKQPYEQ QSSVSMMQTG QGFGYNQAHF
QPGHGPQHAV MMRQKSIGVT EEERQHLHPP AMKLARSLSV PGPEDIPPPP NTSAPEPPLS
AGPYPGRGPA MPIPPISQPH YQLHSQSAHP AQPVWEMGGP GVINQQVMVP TLRRQSDGLC
IREPEAPRRG GGKMGGLRRG YSIGRDGRGV ARRGGRGALI KQSKVEDGLR QHRGKGGATK
EKSSIPIPTI IVKAPSTSSS GRSSQGSSME ADVAPTVSSQ QNLENQDGQP KSAPSVYGNQ
PTTTFIHPLT GKVLDPSSPL GLALAARERA LKDDRRTRRD DRHFGRQLST VGSFPTPIQT
PTPSLFATPT QSAYTSPVSL HLGSPSVTTS PSSLSRPQSP RILRLGGGGE RVEREREGGP
KEGLRVRFSE DKNSQFPTQY YPQSSREKEK EMYEREHAQP VQPPPPPAQP APRRPSYLHM
ENIPNTSYIP QYTVPTAPSQ TNDTVGEARA GAGGLGLMVL PPPAPSIDVD EEFVFADPLP
PPLQFANGKN ERALEFSQHH SHHISSVAPP PPPPPPSPKP QNPPQQSSQA SSDYTMAGVK
VSISTGNKET DPTHSSAVIP KSGDWQDTVV DSGIEELDSH SSSDHHLEML GLSGLRGEKI
GHGGNAQGRE GEKVSDHQDT CITYRGGQTF ELHTSKLANP VFPKMTHYKE HKQSRPRIED
GFSSALAQVG VQHGGMVMEG RRLHSPFSGV KANIINELSS KLQQMSSMRS MDDWSHAPKS
PNIHRLMPTS PVHSHPPHSP TYCPYPTSPK HRSKLRRQTF DFQCSPSKEM RSSVSRRRAP
SPLIYSTEQP NPTPPRPSSL PILPSTPIYS NPFDFPASSP LHLPPSPSCL NYPHLSPAPP
AKPFAIKPLP YWTKYDVADW LTYLNLGEHR ERFIDNEIDG SHLPSLTKDD FLDLGVTRVG
HRMNIERALK KLTDR
//
