ID A0A3Q2FPF7_CYPVA Unreviewed; 777 AA.
AC A0A3Q2FPF7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=N-acetyl-alpha-glucosaminidase {ECO:0000313|Ensembl:ENSCVAP00000007405.1};
GN Name=NAGLU {ECO:0000313|Ensembl:ENSCVAP00000007405.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000007405.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000007405.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_015234818.1; XM_015379332.1.
DR AlphaFoldDB; A0A3Q2FPF7; -.
DR STRING; 28743.ENSCVAP00000007405; -.
DR Ensembl; ENSCVAT00000003369.1; ENSCVAP00000007405.1; ENSCVAG00000009060.1.
DR GeneID; 107087648; -.
DR KEGG; cvg:107087648; -.
DR CTD; 4669; -.
DR GeneTree; ENSGT00390000005900; -.
DR OMA; YGQPFVW; -.
DR OrthoDB; 1112009at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 1.20.120.670; N-acetyl-b-d-glucoasminidase; 1.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR007781; NAGLU.
DR InterPro; IPR024732; NAGLU_C.
DR InterPro; IPR024240; NAGLU_N.
DR InterPro; IPR024733; NAGLU_tim-barrel.
DR PANTHER; PTHR12872; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR12872:SF1; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR Pfam; PF05089; NAGLU; 1.
DR Pfam; PF12972; NAGLU_C; 1.
DR Pfam; PF12971; NAGLU_N; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..777
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018563623"
FT DOMAIN 42..124
FT /note="Alpha-N-acetylglucosaminidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12971"
FT DOMAIN 139..473
FT /note="Alpha-N-acetylglucosaminidase tim-barrel"
FT /evidence="ECO:0000259|Pfam:PF05089"
FT DOMAIN 482..740
FT /note="Alpha-N-acetylglucosaminidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12972"
FT REGION 749..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 88247 MW; BE8467F861CA6E68 CRC64;
MTPRSLLLLL LVAPALFPAV LCRFSTLDHL KPKASEATQA RAVTGLLRRL LGNRSTEFLL
SVNRSLSNNS LDVCELSSAR DGRIVASGSS GVALASGIYN YLKYFCNCQV SWSGKQLELP
SPLPQLSGVL RISSPHRFRY YQNVCTVSYS SVWWDWSRWE TEIDWMALNG INLPLAFTGQ
EALWEEVYRA MGLNETELEE FFSGPAFLAW NRMANMGRFG GPLPPSWHVD QLQLQFKILQ
RMRAFGMIPV LPAFSGNIPK GILRLFPKAN VTRLGPWAHF NCSFSCSYIL DPRDPLFLQI
GSLYLSQVVK TFGTDHIYNT DTFNEMTPPS SDTNYLSAVS RSVFASMTAV DPDAIWLMQG
WLFYSDPSFW KPPQIQALLH GVPLGRMIVL DLFAEADPVF TYTESFYGQP FIWCMLHNFG
GNNGFFGTVE SINSGPFQAL SFPNSTLVGL GMTPEGIEQN PVIYELMSEL AWRREPVNLT
KWVSLYAARR YGSMDDKLTA AWRLLLGGVY NCTWLHYVNH NHSPLVRRPS LKMRTDLWYD
PADLLEAWKL FMDAAPTFMS KETFQYDLVD LTRQVLQDLT SSFYQDIADA YANKKMAELL
TAGGVLVYDL LPELDRLLSS NQNFLLGTWL ERARSKALNE REAQLYDMNA RNQITLWGPS
GEILDYANKQ WGGLVEDYYA QRWALFVHTL VDCLDRAVPF KQDSFNQAVF QVEQGFISNG
RNYSSKPQGD TFQIARRIFL KYHPQALKRL QRTGPGGPPR PRSQRRFSHS SDLQSSD
//
