ID A0A3Q2FPQ3_CYPVA Unreviewed; 574 AA.
AC A0A3Q2FPQ3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Neuroepithelial cell transforming 1 {ECO:0000313|Ensembl:ENSCVAP00000007555.1};
GN Name=NET1 {ECO:0000313|Ensembl:ENSCVAP00000007555.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000007555.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000007555.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_015246516.1; XM_015391030.1.
DR AlphaFoldDB; A0A3Q2FPQ3; -.
DR STRING; 28743.ENSCVAP00000007555; -.
DR Ensembl; ENSCVAT00000003105.1; ENSCVAP00000007555.1; ENSCVAG00000009213.1.
DR GeneID; 107095059; -.
DR KEGG; cvg:107095059; -.
DR CTD; 10276; -.
DR GeneTree; ENSGT00940000155849; -.
DR OMA; KRHWIDS; -.
DR OrthoDB; 24012at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF4; NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 180..362
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 392..507
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 31..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 65106 MW; 568C12CB5992EEE4 CRC64;
MEENEEVYGV TAENPRKKLR RISSRTSICS VISAAEPSPP RLRRNNSKKP PLQRGSSFTF
LAPGTPWDFS LKRKRKEKED DTVSLSSFDL KEPNNKRVRS LAKVSSLVNL MSPSKNGAVR
RFGQSIQSMS VRGDGKSPGT TLKAVSKASG PTPTKRRNST LWSETLDVHQ KRAFSAKEIK
RQEAIHELFR GEQDLIEDLQ LARKAYHDPM LKLSIMTQEE LAHIFGDLDA YIPLHEYLLM
KLTEGTGPDG TVAQIGQIVI DWLPGLNAYK NYCSNQLAAK ALLDQKKQDK RVQDFLQRCL
ESPFSRKLDL WSFLDIPRSR LVKYPLLLRE ILRHTPPDHP DVASLERAIT IIQDILSDIN
VRKGESECQY YIDKLEFLDE KQRDPLIDEC RTLLCHGELR TKSGSRLHVF LFSELLVLTR
PVTRNDRSCF QVYRQPIPVR DLVLEDLQDG EVRLGGSFRG AFTNGEKAKN IFRVSSVDPS
HGQTHTLQVG DVYHKQQWLN CLRTAITQQQ GAPARVQQEG SNLPSSISPG KICKEETDEN
RPPAAAPKLR RQTLSKGRLE QKLQGSQRRK ETGV
//
