ID A0A3Q2FU40_CYPVA Unreviewed; 502 AA.
AC A0A3Q2FU40;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Cdc42-interacting protein 4 homolog {ECO:0000313|Ensembl:ENSCVAP00000010490.1};
GN Name=TRIP10 {ECO:0000313|Ensembl:ENSCVAP00000010490.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000010490.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000010490.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the FNBP1 family.
CC {ECO:0000256|ARBA:ARBA00009426}.
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DR RefSeq; XP_015256347.1; XM_015400861.1.
DR AlphaFoldDB; A0A3Q2FU40; -.
DR Ensembl; ENSCVAT00000017197.1; ENSCVAP00000010490.1; ENSCVAG00000012635.1.
DR GeneID; 107101804; -.
DR CTD; 108179043; -.
DR GeneTree; ENSGT00950000183047; -.
DR OMA; EQECKFS; -.
DR OrthoDB; 2995634at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07653; F-BAR_CIP4-like; 1.
DR CDD; cd11628; HR1_CIP4_FNBP1L; 1.
DR CDD; cd11911; SH3_CIP4-like; 1.
DR Gene3D; 6.10.140.470; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15735:SF17; CDC42-INTERACTING PROTEIN 4; 1.
DR PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51860; REM_1; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..263
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 323..400
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 442..502
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 310..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..202
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 330..357
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 313..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 57467 MW; 2DE5742B6A266718 CRC64;
MDWGTDLWDQ NDVIDKHTQS GLDLLERYIK FVKERTEIEQ NYAKQLRNLT KKYSKRGSKD
EQDCKFSNHA SFQEILNELN DYAGQRELIA ENMMAKICDK LNKDLQDLKQ ERKTHLSDAK
KAQQNLESSF KHLESIKKRF AKEWAEADKA TQQAEKIESE ANVTKSDVDK AKNNALARTR
AAEDCRNNYA AELQKYNKEQ NNFYYTEIPL IFNKLQDMEE RRIRQLAEGY CLFSDIEKNV
LSIISKCLEG IAAAGTKIDE KKDSKLLIEQ HKSGFERPAD VEFEDYSHGV KPSNSESSLN
PLKGRKHKIF KKHKPPPAED FSHLPPEQRK KKLQAKIEDI TKELTKEQDQ SEALDKMRGV
YEQNPQMGDA QSLEPQITQT NQNIGRLRGE LAKYETWLSE AVGVEDSLHT TNNNSQFGGT
ATQNSLGNDY TEFDDEFEDV ESPVGQCTAL YTFKGNSAGT ISITEGEQLS VMEQDKGDGW
MRVLRANGEE GYIPTSYVRV TP
//
