ID   A0A3Q2FU46_CYPVA        Unreviewed;      1041 AA.
AC   A0A3Q2FU46;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Signal-induced proliferation-associated 1 {ECO:0000313|Ensembl:ENSCVAP00000010500.1};
GN   Name=SIPA1 {ECO:0000313|Ensembl:ENSCVAP00000010500.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000010500.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000010500.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2FU46; -.
DR   STRING; 28743.ENSCVAP00000010500; -.
DR   Ensembl; ENSCVAT00000017215.1; ENSCVAP00000010500.1; ENSCVAG00000012664.1.
DR   GeneTree; ENSGT00940000160644; -.
DR   OMA; PYDNIGG; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 6.10.140.210; -; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15711:SF14; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED PROTEIN 1; 1.
DR   Pfam; PF21022; Rap-GAP_dimer; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          469..684
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          33..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          65..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          243..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..81
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..281
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1041 AA;  115937 MW;  9311ACBE9351C57F CRC64;
     MQSDDLFIRK FRRQNMRPPL ATVNFDPKRE AGVVEWPPRR PGDGADADCS LTPSRVGLNL
     RSVGRGPIMQ RSNSDVTLGD LDSSGKTGGK VIRAVGEKVG TGPQGDSGMH LHREYGSLSS
     LERQSQAQEP GGENQGPLSP SALRFKDPFL LLGLEGNPPE PDGFFRDLPR PIGDSPKPAK
     PPKPEGLNKK SKPLPPQISQ PGPYEQLGGG AWVRNFAHYD VQSILFDLTE VATNRDSIGR
     KKNITSGASA ASQLRPLAQS TPASPAQGGG GSGGNTDDQE QSLLLDEGDG NDNELLLSCP
     HFRNETGGEE QVGLGRSPGR RELWSSLRTP NDAVSVLEEP RESNIQLQGK SNFFIEHADL
     GAHYYRKYFY LKHQNFFGID DRLGPVAISF RRDEKEGSSG AQYNYRIIFR TTEMKTLRGS
     ILEESVPSAA RHTTPRGLSP KRLLEFIMPE LNLHCLRLAS NSPKVRDTLL KLDEQGLNFQ
     RKVGVMYCRA GQSSEEDMYN NESSGPAFEE FLDLLGERVR LKGWEKYRAQ LDNKDSTGTH
     SLYTRYQDYE IMFHVSTMLP YTANNTQQLL RKRHIGNDIV TIVFQEPGAL PFTPKSIRSH
     FQHVFIIVQV HEPGTDHTYY VAVTRSKDIP LFGPLFPKGA RFPRVPAFRD FLLAKVVNAE
     NAAEKSEKFR SMATRTRQEY LKDLAENYVT TTPIDSSTKF PLLSLGSKRK DKMKGAKGAE
     LHSAGALVWA VMVNSSDDPE AGEQQKLPCL LGVSAESVVL IERCSRRVVF NCSCRDVIGW
     KAMTETKDGG PCLDVFYERG DSVSISMLES QTEDMKEVVQ RLELVTRGCE ALEVTPLRDG
     VGQPGFLMNE EGFVTDLQRF CYAESGGLQL WARVVRLCGH SLLHLSPEER SRLLRTAHKI
     HITVIPPDEN GKPRSFSELY QKAIKDAECK SGEDQSGLAW VVEEREEEKP EQEQKTEDQA
     KVDKVDVEEV TEEELKVDQL CDMQPNQESH SLLLEPPTLP LLRATSLQDQ PANHSEEVSV
     SQLTRSVSLE KQLSYTDTCD G
//