ID   A0A3Q2G0K4_CYPVA        Unreviewed;       789 AA.
AC   A0A3Q2G0K4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Discs large MAGUK scaffold protein 3 {ECO:0000313|Ensembl:ENSCVAP00000014985.1};
GN   Name=DLG3 {ECO:0000313|Ensembl:ENSCVAP00000014985.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000014985.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000014985.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2G0K4; -.
DR   Ensembl; ENSCVAT00000022941.1; ENSCVAP00000014985.1; ENSCVAG00000017755.1.
DR   GeneTree; ENSGT00940000159565; -.
DR   OMA; WYEQAIP; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd12029; SH3_DLG3; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR035763; DLG3_SH3.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF28; DISKS LARGE HOMOLOG 3; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF10608; MAGUK_N_PEST; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM01277; MAGUK_N_PEST; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          76..163
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          171..258
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          326..407
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          441..511
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          599..774
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   789 AA;  87335 MW;  241CAD398148E324 CRC64;
     MSGGGPGGPN PKGQSKGGPK VNGNNSSGQG GWWPECTCTN REWYDQANPP PIIVNADSLD
     AGPYVNGSDG MYKYEEIILE RGNSGLGFSI AGGIDNPHIP DDPGIFITKI IPGGAAAMDG
     RLGVNDCVLR VNDVDVSEVV HSRAVEALKE AGPVVRLLVR RRQAPPETIL EVNLLKGPKG
     LGFSIAGGIG NQHIPGDNSI YITKIIEGGA AQKDGRLQTG DRLLAVNNIV LQDVRHEEAV
     AALKNTSDMV YLKVAKPGPV HLNDMYAPPD YSSTFPTMVD NHVSHNYMGA MEPKPVYPPP
     QVTPSRYSPV PRHMLGEEDF TREPRKVVLH KGSTGLGFNI VGGEDGEGIF VSFILAGGPA
     DLSGELRRGD RILSVNGVNL RNATHEQAAA ALKRAGQTVT IIAQYRPEEY SRFESKIHDL
     REQMMNSSMS SGSGSLRTSE KRSLYVRALF DYDRTRDSCL PSQGLSFSYG DILHVINASD
     DEWWQARLVT PHGESEQIGV IPSKKRVEKK ERARLKTVKF HARTGMIESN RPVKVKRKKS
     FNLSRKFPFY KSKENIVADL VESEQCLTSN TSDSESSSKG QEDTILSYEP VIRQEITYTR
     PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRENEI DGQDYHFVGS REQMEKDIQD
     NKFIEAGQFN ENLYGTSILS VRTVAERGKH CILDVSGNAI KRLQQAQLYP IAIFIKPKSI
     EALMEMNKRQ TYEQANKVFD KAVKLEQDFG EYFTAIVQGD SLEEIYNKIK LIIEEQSGPY
     IWIPSPEKL
//