ID A0A3Q2G347_CYPVA Unreviewed; 909 AA.
AC A0A3Q2G347;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Toll like receptor 5 {ECO:0000313|Ensembl:ENSCVAP00000016735.1};
GN Name=TLR5 {ECO:0000313|Ensembl:ENSCVAP00000016735.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000016735.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000016735.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR STRING; 28743.ENSCVAP00000016746; -.
DR Ensembl; ENSCVAT00000025201.1; ENSCVAP00000016746.1; ENSCVAG00000019730.1.
DR Ensembl; ENSCVAT00000025208.1; ENSCVAP00000016735.1; ENSCVAG00000019730.1.
DR GeneTree; ENSGT00940000162464; -.
DR OMA; AQSRYFC; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF525; TOLL-LIKE RECEPTOR 5; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 676..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 727..872
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 909 AA; 103329 MW; BE462F0982E5CAFA CRC64;
MVPMQTYAHG VNTGTVYLSQ DEDRMWRLLL HLICTGFYLQ LTTCHPLCQL SGQKVYCAAR
KLRWVPALPP NTTHLYLDRN HIQEINRTSF RDLEELQELD LGSQREVVLT IRNDSFLRQR
KLTLLVLGDN LGLTLEPRAF VGLVSLLDLW LDHCSLTDSI LKENYLEPLL SLNRLNLYGN
KIVRLLPGRF FLNLTRFSVL TLELNSLEKI CEGDLVGFRG KSFKSLDLSS NSFFGSNVDW
STCGNPFRGI TFNRLDISGN GMNLEKLKQF FRAIRGTPIA HLKCSNGLGK GFSHENIADP
DNDTFVGLMD SSVIKLDLSG NRIFALKEKV FRPLRNANSI DISQNKVNII EKNAFFGLQT
NLYKLNLSFN LLGEIRSNTF NGLTELLILD LSHNHIGVLG YKAFSGLPQL HHLYLTGNSL
RLLGSPAALP NLNFLLLRDN KLDSLYPIFS SWNNVIYLDI SGNKLTNLEN VYIVLTHFRH
LVYLLHGDNP ILWCTINAGV SMPGNSSLIV LDLHGCSLQN AWAQGKCLDI FELLQNLLTL
NISLNSLMAL PHGIFSGLTS IDTIDLSSNA LTYLETSVFP ASLRWLDLSN NFLATPNPMT
FHSLIHLDLA GNRFHCDCFL DSFLSWLNTT NVTFRSPVQE YRCKFPASVH NIPLLEFSTI
MEPCEDEEKT VQALRLALFM SSVSLVFSFV LGGIIYARLR GQIFFIYKKI VSRVLEGPKP
PTTEKDWQYD AFLCFSNSDY SWVEAALLEK LDNQFSEENL FHCCFEARDF LPGEDHLSNI
RDAIWSSRKT LCIVSKEFLK DGWCLEAFTL AQGRMLEELT NVLIMLVVGK VAPYQLMRYN
AVRTFVQKRK YLTWPEDPQD LQWFYERLVS LILRDTKVKK FGIEKPEPAD PEGRPPDGEI
ELKNIAAVD
//