ID   A0A3Q2G631_CYPVA        Unreviewed;       411 AA.
AC   A0A3Q2G631;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Zic family member 2 {ECO:0000313|Ensembl:ENSCVAP00000018730.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000018730.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000018730.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC       {ECO:0000256|ARBA:ARBA00010831}.
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DR   AlphaFoldDB; A0A3Q2G631; -.
DR   Ensembl; ENSCVAT00000027744.1; ENSCVAP00000018730.1; ENSCVAG00000022025.1.
DR   GeneTree; ENSGT00940000160645; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR041643; Znf_ZIC.
DR   PANTHER; PTHR19818:SF27; ZINC FINGER PROTEIN ZIC 2; 1.
DR   PANTHER; PTHR19818; ZINC FINGER PROTEIN ZIC AND GLI; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   Pfam; PF18366; zf_ZIC; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          273..300
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          301..330
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          331..360
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          361..383
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
SQ   SEQUENCE   411 AA;  46353 MW;  33CF460C07CF8EFD CRC64;
     MLLDAGHQFP GLGVGSFARH HSASDMQDRD LSLAQNSFVD SAHMGAFKLN HDLSPGQSSA
     FTTQAPGYPA AALGAHAAHV TSYASSPFNS TRDFLFRSRG FGESSPASGQ HAIFGPTAGS
     LHHTHTDTQS HILFPGIHDQ HGSHGSPNVL NGQMRLGLPG EVFGRSEQYH QVSSPRTDPY
     SAAQLHNQYG SMNMNMGMNM AAHHHHHPGA FFRYMRQQCI KQELICKWID PEQLSNPKKC
     CNKTFSTMHE LVTHVSVEHV GGPEQTNHIC FWEDCARESK PFKAKYKLVN HIRVHTGEKP
     FPCPFPGCGK VFARSENLKI HKRTHTGEKP FQCEFEGCDR RFANSSDRKK HMHVHTSDKP
     YLCKMCDKSY THPSSLRKHM KVNILYNIYV YYLEFLHLFA NHLMLLFFIN F
//