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Database: UniProt
Entry: A0A3Q2G692_CYPVA
LinkDB: A0A3Q2G692_CYPVA
Original site: A0A3Q2G692_CYPVA 
ID   A0A3Q2G692_CYPVA        Unreviewed;      1246 AA.
AC   A0A3Q2G692;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Calcium-transporting ATPase {ECO:0000256|RuleBase:RU361146};
DE            EC=7.2.2.10 {ECO:0000256|RuleBase:RU361146};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000018825.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000018825.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the hydrolysis of ATP coupled with the transport of
CC       calcium. {ECO:0000256|RuleBase:RU361146}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate;
CC         Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:456216; EC=7.2.2.10;
CC         Evidence={ECO:0000256|RuleBase:RU361146};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU361146}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU361146}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IIB subfamily. {ECO:0000256|RuleBase:RU361146}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU361146}.
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DR   RefSeq; XP_015256072.1; XM_015400586.1.
DR   AlphaFoldDB; A0A3Q2G692; -.
DR   Ensembl; ENSCVAT00000027869.1; ENSCVAP00000018825.1; ENSCVAG00000022167.1.
DR   GeneID; 107101601; -.
DR   CTD; 491; -.
DR   GeneTree; ENSGT00940000166500; -.
DR   OrthoDB; 847at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0005388; F:P-type calcium transporter activity; IEA:UniProtKB-EC.
DR   CDD; cd02081; P-type_ATPase_Ca_PMCA-like; 1.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 3.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR022141; ATP_Ca_trans_C.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006408; P-type_ATPase_IIB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01517; ATPase-IIB_Ca; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 3.
DR   PANTHER; PTHR24093; CATION TRANSPORTING ATPASE; 1.
DR   PANTHER; PTHR24093:SF377; PLASMA MEMBRANE CALCIUM-TRANSPORTING ATPASE 2; 1.
DR   Pfam; PF12424; ATP_Ca_trans_C; 1.
DR   Pfam; PF13246; Cation_ATPase; 1.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 2.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00121; NAKATPASE.
DR   SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SMART; SM00831; Cation_ATPase_N; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361146};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU361146};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW   ECO:0000256|RuleBase:RU361146};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361146};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361146};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU361146};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361146};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361146}; Transport {ECO:0000256|RuleBase:RU361146}.
FT   TRANSMEM        403..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        446..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        881..902
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        958..976
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        996..1014
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   TRANSMEM        1034..1054
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361146"
FT   DOMAIN          49..123
FT                   /note="Cation-transporting P-type ATPase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00831"
FT   REGION          362..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1178..1216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..383
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1201..1216
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1246 AA;  137358 MW;  DF87240BDCDF2D19 CRC64;
     MGDMSNSDFY AKNQRKESNH AAGFGCSVME LRSLMELRGT EAVVKLQEDY GAVEGLCMRL
     KTSPTEGLAG VQTDLDKRRE IFGKNLIPPK KPKTFLQLVW EALQDVTLII LEIAALISLG
     LSFYHPPGQT SGEACGAAAG GVEDEGEADA GWIEGAAILL SVVCVVIVTA FNDWSKEKQF
     RGLQSRIEQE QKFQVVRGSQ VIQLPVADIV VGDIAQIKYG DLLPADGVLI QGNDLKIDES
     SLTGESDHVK KAADKDPMLL SGTHVMEGSG RMVVTAVGVN SQTGIIFTLL GASVEEEEKK
     EKKDCSHPPI HPIATIATDG AAGINAPGTA SLINGKMQDG NMESNQIKVK KQDGAAAMEM
     QPLKSAEGGE ADEKERKRVS APKKEKSVLQ GKLTKLAVQI GKAGLLMSAI TVIILVLYFA
     IDNFVMEKRP WMPECTPVYI QYFVKFFIIG VTVLVVAVPE GLPLAVTISL AYSVKKMMKD
     NNLVRHLDAC ETMGNATAIC SDKTGTLTTN RMTVVQCYIG DVHYKKIPDP GVIPPKTLEL
     LINAIAINSA YTTKILPPDK EGGLPKQVGN KTECGLLGLI LDLKRDYQPI RNQIPEEKLY
     KVYTFNSVRK SMSTVIKLTD GSFRMYSKGA SEIVLKKCSH ILNEVGEPRV FRPRDKDEMV
     KKVIEPMACE GLRTICVAYR DFPRDPEPKW DDENNILSDL TAICVVGIED PVRPEVPDAI
     LKCQRAGITV RMVTGDNINT ARAIAIKCGI IHPGEDFLCI DGKEFNRRIR NEKGEVEQER
     IDKVWPKLRV LARSSPTDKH TLVKGIIDST MADQRQVVAV TGDGTNDGPA LKKADVGFAM
     GIAGTDVAKE ASDIILTDDN FSSIVKAVMW GRNVYDSISK FLQFQLTVNV VAVIVAFTGA
     CITQDSPLKA VQMLWVNLIM DTFASLALAT EPPTESLLKR KPYGRNKPLI SSTMTKNILG
     HAVYQLIIIF TLLFIGEKIF DIDSGRNAPL HSPPSEHYTI IFNTFVMMQL FNEINARKIH
     GERNVFEGIF RNPIFCSIVF GTFAIQIVIV QFGGKPFSCQ PLDLEKWMWC VFLGMGELVW
     GQVIATIPNS NLRFLRRAGQ LTQKDELPED DVNEENEEID HAERELRRGQ ILWFRGLNRI
     QTQIRVVNAF RSSLYEGLEK PDSRTSIHNF MTHPEFRIDD STPSIPLIDD TDDDSARRRT
     KYSSQPSSPN KNNNAIDSGI NLTIDISKSA ASSSPASPLH SLETSL
//
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