ID   A0A3Q2G6J6_CYPVA        Unreviewed;       500 AA.
AC   A0A3Q2G6J6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 3 {ECO:0000313|Ensembl:ENSCVAP00000019015.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000019015.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000019015.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   RefSeq; XP_015245012.1; XM_015389526.1.
DR   AlphaFoldDB; A0A3Q2G6J6; -.
DR   STRING; 28743.ENSCVAP00000019015; -.
DR   Ensembl; ENSCVAT00000028094.1; ENSCVAP00000019015.1; ENSCVAG00000022343.1.
DR   GeneID; 107094107; -.
DR   CTD; 956; -.
DR   GeneTree; ENSGT01100000263542; -.
DR   OMA; GNAISDM; -.
DR   OrthoDB; 180318at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF38; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        472..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        174
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         214..218
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   500 AA;  56511 MW;  65188814A94AC28E CRC64;
     MASQKKIGYK CRIAGVMLLL LGSIAALVVV AVIQDKLKVE EYGSEYGIVI DSGSSRSNVY
     LYEWPGEKEN ETGVVKEKMN CAVKGVPISE LKVSSKDDET TFKAFQDCMD DIKRHIPEEK
     HKTTPLFLGA TAGMRLLHAK DKKRSDEIMT SLREYLSGLN FEFHNASIIT GQEEGLYGWI
     TVNYLKGNFL EKNMWNTYVR PNGAETFGSM DLGGASTQIA FQVQEKGQGP DYMLVKLYGY
     PYTIYTHSFL CYGKNEADKR VLDKIIKESS DPAYIINPCY PDGFNYTMSA SAIYDTECTM
     KPKNYKPDLQ FFMVGKSDSK KCGEIVKSIF DFKNCSSKMC SFNGVEQPPV TGEFMAYAGF
     FYIARALGMN GTSKLEEFNI SVGNFCQTYW TELKTKHPKI HEKFLKTYCF ASHYVLTLLA
     DGYKFDEETW KNIHFEKTVK ETNIGWSLGY MLSMSNMIPS EVKVITPMTN PVFAGLIFLF
     SALIIITVVL GFIILIRTCY
//