ID A0A3Q2GBU7_CYPVA Unreviewed; 173 AA.
AC A0A3Q2GBU7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=von Hippel-Lindau tumor suppressor {ECO:0000313|Ensembl:ENSCVAP00000022345.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000022345.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000022345.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VHL family. {ECO:0000256|ARBA:ARBA00010057}.
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DR RefSeq; XP_015244894.1; XM_015389408.1.
DR AlphaFoldDB; A0A3Q2GBU7; -.
DR STRING; 28743.ENSCVAP00000022345; -.
DR Ensembl; ENSCVAT00000009528.1; ENSCVAP00000022345.1; ENSCVAG00000004961.1.
DR GeneID; 107094015; -.
DR KEGG; cvg:107094015; -.
DR CTD; 7428; -.
DR GeneTree; ENSGT00390000014353; -.
DR OMA; VGHPWLF; -.
DR OrthoDB; 2951928at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR CDD; cd05468; pVHL; 1.
DR Gene3D; 1.10.750.10; von Hippel-Lindau disease tumour suppressor, alpha domain; 1.
DR Gene3D; 2.60.40.780; von Hippel-Lindau disease tumour suppressor, beta domain; 1.
DR InterPro; IPR024048; VHL_alpha_dom.
DR InterPro; IPR037139; VHL_alpha_dom_sf.
DR InterPro; IPR024053; VHL_beta_dom.
DR InterPro; IPR037140; VHL_beta_dom_sf.
DR InterPro; IPR036208; VHL_sf.
DR InterPro; IPR022772; VHL_tumour_suppress_b/a_dom.
DR Pfam; PF01847; VHL; 1.
DR Pfam; PF17211; VHL_C; 1.
DR SUPFAM; SSF49468; VHL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 12..91
FT /note="von Hippel-Lindau disease tumour suppressor beta"
FT /evidence="ECO:0000259|Pfam:PF01847"
FT DOMAIN 105..152
FT /note="von Hippel-Lindau disease tumour suppressor alpha"
FT /evidence="ECO:0000259|Pfam:PF17211"
SQ SEQUENCE 173 AA; 20300 MW; 399005099F1A253E CRC64;
MPQEGEQPLP LVRSVNSAIP RNVVFCNRTS RVVRPLWIDY RGEPQPYDDL QPGSGRRMIT
YVGHPWIFRD AGTDEPLKVN HKELFVPKPS DEDELYVNIT LQVDSLKDRA LHAVRRLVRP
EDYRRLEIAR CLQEELENQP SHLKDLQRLN RRVEQQLLEN IRRREGAESQ ETG
//
