ID A0A3Q2GCG5_CYPVA Unreviewed; 848 AA.
AC A0A3Q2GCG5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=RNA binding motif protein 5 {ECO:0000313|Ensembl:ENSCVAP00000022760.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000022760.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000022760.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_015248118.1; XM_015392632.1.
DR AlphaFoldDB; A0A3Q2GCG5; -.
DR STRING; 28743.ENSCVAP00000022760; -.
DR Ensembl; ENSCVAT00000008544.1; ENSCVAP00000022760.1; ENSCVAG00000005655.1.
DR GeneID; 107096122; -.
DR KEGG; cvg:107096122; -.
DR CTD; 10181; -.
DR GeneTree; ENSGT00940000156617; -.
DR OMA; CESEHER; -.
DR OrthoDB; 298711at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12755; RRM2_RBM5; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR041591; OCRE.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034993; RBM5_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR13948:SF21; RNA-BINDING PROTEIN 5; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF17780; OCRE; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 2.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022728};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00022728};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 102..182
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 185..214
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 235..319
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 679..709
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 776..822
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 94395 MW; 28652E9A544FFF27 CRC64;
MGADKRISRT ERSGRYGSEH YRDDPDWRDR RDRDQDRDHS SRRWSEERRD RYDGDRRGPR
DSPEQRERKR RNSDRSEDGY HSDGDYQEQD YRREPGDDKK SKTIMLGGLS SQTTEEDIRF
AIDQLEGPQP VDVRLMKKRT GISRGFAFVD FYHLQDATRW METNQKRLVI QGKVVDMHYS
HPRNKYEDWL CNTCGLYNFR RRLKCFRCGA AKADGEMGNA TGATELQPTG DFYGDTIILR
NIAPQTTVEA ILTALAPYAN LSANNIRLIK DKQTGQNRGF AFVQLSSPLE ASQLLTILQG
LQPPLKLDGK TIGVDYAKSA RKDLLLPDGN RVSAFSVAST AIAAAQWSSA QPQQTMDGMS
EYACLQEGYA PLPQDYHTYY QPGAVATTCQ GNGILGAAPG VKLVPAAVVI SQSPQIYQPH
IIAQPAVQLD GKAQVGLAAV ESVAVPALAG AAASVCGTSA IPASGTSLET TSAHVPDTST
YQYDESSGYY YDPQTGLYYD PNSQYYYNTQ TQQYLYWDSE KQTYVPAPGN TNPGQNDKAN
GSAGGNKEPK EKKEKPKSKT AQQIAKDMER WAKSLNKQKE NFKSSFQPIS QEDRKEAAAA
DAGYTLFEKK QGGLDRLMQE VARYAEEEEL PISSANSSKC GLVAAYSGDS DPEEGGGGAG
GETDGGDMSQ DKLTDWKKMA CLLCRRQFPN KEGLMRHQQL SDLHKKNLEV LRRSKMSEAE
LEELERKETE QKYRDRAAER REKYGIPEPP VPKKKKFSQP AAAVNYEQPT KDGLTSDNIG
NKMLQAMGWK EGKGLGRNQQ GITAPIEAQL RTKGAGLGTK GTNYTLSASD TYKDAVRKAM
FARFTELE
//
