ID A0A3Q2GDJ7_CYPVA Unreviewed; 664 AA.
AC A0A3Q2GDJ7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Engulfment and cell motility protein 2-like {ECO:0000313|Ensembl:ENSCVAP00000023470.1};
GN Name=ELMO2 {ECO:0000313|Ensembl:ENSCVAP00000023470.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000023470.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000023470.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR AlphaFoldDB; A0A3Q2GDJ7; -.
DR STRING; 28743.ENSCVAP00000023470; -.
DR Ensembl; ENSCVAT00000006644.1; ENSCVAP00000023470.1; ENSCVAG00000006865.1.
DR GeneTree; ENSGT00940000159236; -.
DR OMA; XDMANAF; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF8; ENGULFMENT AND CELL MOTILITY PROTEIN 2; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 258..427
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
FT REGION 644..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 76299 MW; 4F3CC0B4D20F85E4 CRC64;
MPPPADIVKV AIEWPGANAQ LIEMDQVGIR EKHLHMEQLL ERIQSHGIDA RLEALKELAK
LSADPTFAAE FINMEGIGTL ARLVESGTHF GEMLAFTLTA FLELMDHGIV SWDLISLSFI
KQIAGYVNQP MVDVSILQRS LAILESMVLN SHSLYHRVAQ EITVGQLIGH LQVSNQEIQT
YAIALINALF LKAPEDRRQE MASSLAQKHL RSIILNHVIR GNRPIKAEMA HQLYVLQVLT
FNLLEERMMT KMDPNDQAQR EIIFELRRIA FDGDTDPTGT EKRKAIYTKD YKMLGFTNHL
NPAMDFTQTP PGMLALDNML YLARVHQDTY IRIVLENSSR EDKHECPFGR CAIELTRMLC
EILQVGELPN EGCNDYHPMF FTHDRAWEEF FCVCIQLLNK TWKEMRATAE DFNKVMQVVR
EQITRALAMK PSSIDQLKNK LRCLNYSEIL RLRQSERMSQ DDFQSPPIMC WREVIPPTQY
ILHLLLKTPE LLHCDKTFTI ILLCCFFVEK FWFCRLSLNH KVLHYGDLEE SPQGEVPFEL
LSDKIPVSDI KSVLTGKDCP HMKEKSALKQ NKEVLELAFS VLYDPDETLN FVAPNKYEYC
IWTDGLCALL GREMGSDLTR SDLDTLISME MKLRLLDLEN ITIPEAPPPV PKEPSSYNFS
YNYS
//
