ID A0A3Q2GFT4_CYPVA Unreviewed; 1223 AA.
AC A0A3Q2GFT4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Patched 2 {ECO:0000313|Ensembl:ENSCVAP00000024880.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000024880.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000024880.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR AlphaFoldDB; A0A3Q2GFT4; -.
DR Ensembl; ENSCVAT00000003081.1; ENSCVAP00000024880.1; ENSCVAG00000009322.1.
DR GeneTree; ENSGT00940000159901; -.
DR OMA; DFISAQF; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF3; PROTEIN PATCHED HOMOLOG 2; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 83..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1017..1038
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1044..1066
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1073..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1112..1131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1143..1165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1196..1216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 419..577
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1223 AA; 135440 MW; 5B19BADEFF376306 CRC64;
MASDRGVSGS GVFGDLPPSY MRSPPPAHPD LQRRPSYCHA AFALKQISKG KAVGQKAPLW
IRARFQAFLF SLGCRIQRHC GKVLFIGLLV FGALSVGLRV AAIETNIEQL WVEAGSRVST
ELRYTREKQG EESVFTSQML IQTPKEEGTN ILTQEALLVH MEAALSASKV QVSLFGKSWD
LNKICYKSGV PIIEHVMIER MIDKLFPCMI ITPLDCFWEG AKLQGGSAYL PGMQDIQWMN
LDPVKLMEEL GQYTSLEGFK EMLDKAQVGH AYMDRPCLDP SDPDCPTTAP NKEQEEVLDI
AERLQGGCHG FSQKFMHWQE ELILGGRVKS SQETLLSAEA LQTMFLLMSP KQLYEHFKDD
YLIHDINWNE DKATAILESW QRKFVEVVHQ SIPDNSSQSI HAFSTTTLND IMKSFSDVSV
IRVAGGYLLM LAYACVTMLR WDCAKSQGAV GLAGVLLVAL SVAAGLGLCS LIGLSFNAAT
TQVLPFLALG IGVDDMFLLA HSFTETGSNI PFKEKTGDCL RRTGTSVALT SINNMIAFFM
AALVPIPALR AFSLQAAIVV VFNFAMVLLI FPAILSLDLH RREDKRLDIL CCLYSPCADR
VIHLSPNELS ESGEQSHVPG AGVSHAHQYA AGPTITTSTQ ITTTVQAFTQ CDSAGQHIVT
ILPPTSQIST SVSPSPTTSV PDPYGSQLFT PTSSSTRDLL AQVEDSKSGK KCVPFPFLHW
NLSIFAREKY APLLLKPKSK VAVVVLFLGL LSLSLYGTTM VHDGLYLTDI VPRDTKEYDF
IDAQFKYFSF YNMYLVTMDG FDYARSQRLL IQLHNAFNSV RYVVRDENNK LPRMWLHYFQ
DWLKGLQDAF DADWQAGRIT ADSYRNGTED GALAYKLLIQ TGSKKEPFNH SQLTSRRLVD
DEGLIPPEVF YIYLTVWVSN DPLGYAASQA NFYPHPREWI HDKYDTTGEN LRIPSAEPLE
FAQFPFYLNG LRQASDFVEA IESVRAICDE FSRKGVLNYP NGYPFLFWEQ YIGLRHWFLL
SISVVLACTF LVCAILLLNP WTAGIIVFIL AMMTVELFGI MGLIGIKLSA IPVVILIASV
GIGVEFTVHI ALGFLTAIGN RNKRSAVALE HMFAPVVDGA ISTLLGVLML AGSEFDFIMR
YFFAVLAILT VLGMLNGLVL LPVLLSMMGP PAEVTPVDNA SCLPTPSPEP PLPPPMAHHV
FSCGVCPLFL LFSVLFSDSE KTP
//