ID A0A3Q2GGJ6_CYPVA Unreviewed; 845 AA.
AC A0A3Q2GGJ6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=PMS1 homolog 1, mismatch repair system component {ECO:0000313|Ensembl:ENSCVAP00000025380.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000025380.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000025380.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR AlphaFoldDB; A0A3Q2GGJ6; -.
DR STRING; 28743.ENSCVAP00000025380; -.
DR Ensembl; ENSCVAT00000001762.1; ENSCVAP00000025380.1; ENSCVAG00000010271.1.
DR GeneTree; ENSGT00940000157085; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03485; MutL_Trans_hPMS_1_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 482..550
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 482..550
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 307..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 845 AA; 93040 MW; 79905925E61D9C37 CRC64;
ALFAVLKENF GLERTEVRDN GCGIKAADAP VMAVRHFTSK ICSHEDLERL ESYGFRGEAL
GSICAVAEVS VTTKTQEDDI STQYTLDHTG RVVSQRPSHL GQGTSVSVTK LFKNLPVRRQ
FYSSTKKCKE ELKKVQDLLM AYALIKPELR LMLVHNKAVL WQKARAADLR SALVATLGSG
AVANLLPCHQ EQPEMVLDGF LPKPGADLSS TSCSASEKTF IFINRRPVQQ KEIMKLLRQH
YCAQYAEDAA RHRFPILLLS ISVSPSSLDV NLTPDKTQVL LDNKEAVLTA LEALLVSLYG
FRSSSAEQQL NHEAPPPPSA RSEAKEDQNI RVHEDAPTAE PKHGGGADPQ AALQRQASSC
SSSSSTADDW IINPPPSELC SVSSLCGDET AAARPKPEQT GSEPEKPEEE RETRKISAQD
WSRGTALTDP VTGDPLRPVL VHRPSGPGSP GPQEARSKKL INSVTEKGAT LTAYDMISSR
AMRAPPSPAS LFEKEARSEV LRERPAASLQ EVSAAVQERW RNLREEDRKT YEEKAKKKHD
LHEQRTKLAS DGGPQGPTER AKAQSVKRKA PPSNQQLLDE LFSAQPQKKT KTPPPKPSRP
LLCSMAALRL GLQRLSSQSS APPRGLRLVN RLGSQSCWAV MAGRRLLLFN PYRVEEALLF
KRLQENHVLP AAVLQNPLRL TDGNLGGAEF ETLCSMKKGA AELDGSVFFS DPRLLANGFR
VRLPAGLPSA EKHLEVAAMA DCVPFLGVED LREVLSAVLH RKASRPQDCR PLKVTNYLKA
EAVRLARQLP SSLRRGDVEE LVGRMERRLG GTERTCIHGR RFFHHLVDVP STDEEAEALL
RPLEL
//
