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Database: UniProt
Entry: A0A3Q2GI96_CYPVA
LinkDB: A0A3Q2GI96_CYPVA
Original site: A0A3Q2GI96_CYPVA 
ID   A0A3Q2GI96_CYPVA        Unreviewed;      1910 AA.
AC   A0A3Q2GI96;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE            EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000026560.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000026560.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001490};
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR   Ensembl; ENSCVAT00000016770.1; ENSCVAP00000026560.1; ENSCVAG00000012259.1.
DR   GeneTree; ENSGT00940000155060; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd00063; FN3; 8.
DR   CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR   CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR   CDD; cd14629; R-PTP-F-2; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR46957:SF1; PHOSPHATIDYLINOSITOL PHOSPHATASE PTPRQ; 1.
DR   Pfam; PF00041; fn3; 7.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF13927; Ig_3; 1.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PRINTS; PR00014; FNTYPEIII.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 8.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR   SUPFAM; SSF49265; Fibronectin type III; 5.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   PROSITE; PS50853; FN3; 8.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           33..1910
FT                   /note="protein-tyrosine-phosphatase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018685191"
FT   TRANSMEM        1254..1277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          36..126
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          138..233
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          241..323
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          330..420
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          425..519
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          523..612
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          617..714
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          719..818
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          819..913
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          917..1009
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1012..1096
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1355..1610
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1530..1601
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   DOMAIN          1642..1901
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          1819..1892
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          406..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1910 AA;  213347 MW;  218C872B0C75CDE9 CRC64;
     MVPNIHLAGP LLHRGALLLL FLLGSKVISS LADNRPQFIK TPEDQTGVSG GVASFVCQAS
     GEPRPRITWM KKGKKVSSQR FEVIEFDDGS GSVLRIQPLR THRDEAIYEC TATNSVDEIH
     ASAKLTVLDE DQIPHGFPVI DMGPQLKVVE RTRTATMLCA ASGNPDPEIS WYKDMLPVDI
     NSSNGRIKQL RSGGTPIRGA LQIENSEMSD QGKYECVAMN SAGTRYSAPA NLYVRVRRVP
     PRFSIPPTNQ EVMPGGSVNL TCVAVGSPMP FVKWTMGQLE LTKEEELPLG RNVLEVTNIR
     ESANYTCVAM SSLGVIDATA QVIVKALPKP PTSLTVTETT ATSVTLTWDS GNPEPVSYYM
     IQYRAKSSDN GFQEVEGVAT TRYSIGGLSP YSEYEFRVMA VNNIGRGPPS DPVETRTGEQ
     APSSPPLHVQ ARMLSASTML VQWEPPEEPN GQIRGYRVYY SSDMTAPLSA WQKHNTDDSS
     LTTISGLTPE ITYSLRVLGF TSVGDGPPSD ILQVKTQQGV PAQPSSFEAE AELDSRISLS
     WLWPVQDQIT KYELQYWEAG SDSKKHVTFN PAGSYAVDGL KPDTLYYFSL AARSETGLGV
     YTQPIQARTA QSTPSAPPQE VHVVSLTSTS LKVSWVAPPA DSRHGAIVRY TISYQAPAGE
     DTERHDVSDI GADATSYVLE GLEKWTEYDV WVRAHTDVGP GPESVPVKIR TKEDVPGAPP
     RKLEVDAINS TAIRVTWKPP VQVKQHGQIR GYQVIFSRLE NGEPRGQPNI MDVALPEAQE
     AIIGGLHAET TYSVTVAAYT TKGDGARSKA KVVTTTGAVP GKPTMMISTT MGNTALIQWQ
     PPKEMVGELI GYQLQYKRTD EEAFTSLELS KTKDHHTVTE LHKGATYIFR LSARNRAGAG
     EAYVKEISTT EDKPTGFPLN LKVTGLTQSS TQLTWEPPNL KERNGKITHY LVVYRDINNQ
     QDNTSSTEDT HLTIEGLNPD TTYDIRVQAF TSKGGGPLSP SIQSRTMSND FPTLNFGVKA
     VTKTSVLLTW DLPENHKSQA PFKILYNQQS VEVEGNQKRK LITQLQPDTD YSFVLTSRGI
     IAGGLQQQVS IRTAPDLIKT KPITETPQGG KSTINLPKVQ TTSRVRWYYI VVVPQTESMQ
     RWKNPDEMDL EELLRSREGP VLRRRRHVDS PRAYVAAKLA HLPETFTLGD DKEYMGFRNK
     PLTNQQQYLC FVVAVLRNEG TDGAANYMTF SASPYSDPIH IEPDKAPMTD PPEMLWVMGP
     VLAVVVIIII VIAILLFKKK RASPLPKDEH SGGVKDSLLA NSSDPVEMRR LNYQTPGPSS
     HRCPNTPRMR EHPPIPVIDL ADHIERLKAN DGLRFSQEYE SIDPGQQFTW ENSNMEVNKP
     KNRYANVIAY DHSRVVLTSV DAVPGSDYIN ANYIDGYRKQ NAYIATQGPL PETLSDFWRM
     VWEQRANTIV MMTRLEEKSR VKCDQYWPSR GTETYGMIQV TMLDTVELAT YSVRTFLLYK
     SGSTEKREVR QFQFMAWPDH GVPEYPTPIL AFLRRVKACN PPDAGPMVVH CSAGVGRTGC
     FIVIDAMLER MKHEKTVDIY GHVTCMRSQR NYMVQTEDQY IFIHEALLEA ATCGNTEVPA
     RNLYAHIQKL TQPPSGETVT AMELEFKRLA NSKAHTSRFI SANLPCNKFK NRLVNIMPFE
     STRVCLQPIR GVEGSDYINA SFIDGYRQQK AYIATQGPLA ETTEDFWRML WEHNSTIVVM
     LTKLREMGRE KCHQYWPAER SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTIRQ
     FQFTDWPEQG VPKTGEGFID FIGQVHKTKE QFGQDGPITV HCSAGVGRTG VFITLSIVLE
     RMRYEGVVDL FQTVKTLRTQ RPAMVQTEDQ YQLCYRAALE YLGSFDHYAT
//
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