ID   A0A3Q2GJ17_CYPVA        Unreviewed;      1053 AA.
AC   A0A3Q2GJ17;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Formin like 3 {ECO:0000313|Ensembl:ENSCVAP00000027155.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000027155.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000027155.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the formin homology family.
CC       {ECO:0000256|ARBA:ARBA00023449}.
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DR   RefSeq; XP_015241644.1; XM_015386158.1.
DR   RefSeq; XP_015241653.1; XM_015386167.1.
DR   STRING; 28743.ENSCVAP00000011082; -.
DR   Ensembl; ENSCVAT00000017900.1; ENSCVAP00000027155.1; ENSCVAG00000013561.1.
DR   Ensembl; ENSCVAT00000017975.1; ENSCVAP00000011082.1; ENSCVAG00000013561.1.
DR   GeneID; 107091923; -.
DR   KEGG; cvg:107091923; -.
DR   CTD; 91010; -.
DR   GeneTree; ENSGT00940000159962; -.
DR   OrthoDB; 471257at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030041; P:actin filament polymerization; IEA:Ensembl.
DR   GO; GO:0046847; P:filopodium assembly; IEA:Ensembl.
DR   GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR   GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014767; DAD_dom.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR010472; FH3_dom.
DR   InterPro; IPR043592; FMNL_animal.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   InterPro; IPR010473; GTPase-bd.
DR   PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR   PANTHER; PTHR45857:SF3; FORMIN-LIKE PROTEIN 3; 1.
DR   Pfam; PF06367; Drf_FH3; 1.
DR   Pfam; PF06371; Drf_GBD; 2.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM01139; Drf_FH3; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51231; DAD; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          22..470
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          586..976
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   DOMAIN          1006..1043
FT                   /note="DAD"
FT                   /evidence="ECO:0000259|PROSITE:PS51231"
FT   REGION          517..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          385..412
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          947..1002
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        532..567
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1053 AA;  119378 MW;  00F1091A3462E4AA CRC64;
     MGNVESADGQ SEMKHHIMPL KVPMPDPTEL EEKFAIVLNS MNLPPDKARL LRQYDNEKKW
     DLICDQERFQ VKNPPHTYIQ KLRGYLDPGV TRKKFRRRVQ ESTKVLRELE ISLRTNHIGW
     VREFLNDENR GLDVLVEYLS FAQCAVMLDF EGLENGEDGF LDKAKSWSRS IEDLHHMGAQ
     PFCNTLVRSA HQSVLRYGTL SNSKTIKNSR LVSQKDDVHV CIMCLRAIMN YQYGFNMVMS
     HAHAVNEIAL SLNNKNPRTK ALVLELLAAV CLVRGGHEII LSAFDNFKEV CKEKQRFERL
     MDYFRSEEGN IDFMVACMQF INIVVHSVED MNFRVHLQFE FTKLGLDDFL EKSKHTESDK
     LSVQIQAYLD NVFDVGGLLE DAETKNAALE KVEELEEHLS HVTEKLLEVE NETMMKVADL
     EKLLFQKDKD LQAIRETYES TSTQVNTLRR MIKEKDAAFQ RQVNIERRLL ELEQQGTIRL
     HKKPDGDISI EPLGVGGGGS GIGIPLGNVG QLMLSSTAGL TEPGGLDTSL PPASEAPPPP
     PPPPPPPPPP PSALTAPPPP PPPLPPPLPD ASPSVILSLG LSAIRIKKPI KTKFRLPVFN
     WTALKPNQIN GTVFNEIDDE RVLEELDLEK FEELFKTRAQ GPVVDLSCTK SKVAQKAVNK
     VTLLDANRSK NLAITLRKAN KTTEEICKAI EKFDLKALPV DFVECLMRFL PTEAEVKVFR
     QYERERRPLD QLAEEDRFML LFSKIERLTQ RMNIITFVGN FADSIGMLTP QLNAIIAASG
     SVKSSPKLKR MLEIILALGN YMNSSKRGSV YGFKLQSLDL LLDTKSTDRK MTLLHYIALI
     VKEKYPELAN FYNELHFVDK AAAVSLENVL LDVRELGKGM ELIRRECSMH DHPVLKGFVQ
     ASDPQLDKLQ RDAKTAEEAF NSVVSYFGES AKTTPPSVFF PVFVRFIKAY KDAVEENELK
     KKQEEAMREK LLAQEAKQHD PKVQAQKKRH QQQELIAELR KRQAKDHRPV YEGKDGTIED
     IITVLKSVPF TARTAKRGSR FFCEANLCDD ANC
//