ID   A0A3Q2GLS1_CYPVA        Unreviewed;       307 AA.
AC   A0A3Q2GLS1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Retina and anterior neural fold homeobox {ECO:0000313|Ensembl:ENSCVAP00000029000.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000029000.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000029000.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC       initial specification of retinal cells and/or their subsequent
CC       proliferation. {ECO:0000256|ARBA:ARBA00003750}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC       ECO:0000256|RuleBase:RU000682}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000256|ARBA:ARBA00006503}.
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DR   RefSeq; XP_015231850.1; XM_015376364.1.
DR   AlphaFoldDB; A0A3Q2GLS1; -.
DR   STRING; 28743.ENSCVAP00000029000; -.
DR   Ensembl; ENSCVAT00000030893.1; ENSCVAP00000029000.1; ENSCVAG00000016444.1.
DR   GeneID; 107085811; -.
DR   KEGG; cvg:107085811; -.
DR   CTD; 30474; -.
DR   GeneTree; ENSGT00940000166467; -.
DR   OMA; VMMMDER; -.
DR   OrthoDB; 3042435at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003654; OAR_dom.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; HOMEOBOX PROTEIN, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR46271:SF3; RETINAL HOMEOBOX PROTEIN RX; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          112..172
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DOMAIN          287..300
FT                   /note="OAR"
FT                   /evidence="ECO:0000259|PROSITE:PS50803"
FT   DNA_BIND        114..173
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          60..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        96..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  34011 MW;  44848D64D0F52132 CRC64;
     MWLLGSPSQM MMMMEERTSP SVRSAQSPGN NPATVHSIEA ILGFKEDTIF HKSAPYTETI
     KDSEHSGKDT VTQRKKSHYT DSCDSVCSGE ASAGPDSPDR DGRLSDDENQ KKKHRRNRTT
     FTTFQLHELE RAFEKSHYPD VYSREELALK VNLPEVRVQV WFQNRRAKWR RQEKLEVSAI
     KLQDTPSPSL LSFGRSTSTL GSTLPLEPWL SSPITSSASL QSLPGFISGS QSLQGAYTPS
     PPPSIPSSLP ASIFTSPALG HSSHLPHISS MCPTPPTYQC SVNPKNSSIA SLRMKAKEHI
     QSIGKTW
//