ID A0A3Q2GMY3_CYPVA Unreviewed; 858 AA.
AC A0A3Q2GMY3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
GN Name=DPP9 {ECO:0000313|Ensembl:ENSCVAP00000029825.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000029825.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000029825.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC Pro nor hydroxyproline.; EC=3.4.14.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001257};
CC -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC {ECO:0000256|ARBA:ARBA00010036}.
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DR AlphaFoldDB; A0A3Q2GMY3; -.
DR STRING; 28743.ENSCVAP00000029825; -.
DR Ensembl; ENSCVAT00000023198.1; ENSCVAP00000029825.1; ENSCVAG00000017971.1.
DR GeneTree; ENSGT00940000158174; -.
DR OMA; VTHMTPQ; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR045785; Dpp_8/9_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF193; DIPEPTIDYL PEPTIDASE 9; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF19520; Dpp_8_9_N; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 24..145
FT /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19520"
FT DOMAIN 186..569
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 658..858
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 858 AA; 97866 MW; A4982D7633D847CA CRC64;
MCCPCSCRTA SGMAVDGLWD STEVVEMDDV PSQFFVEKHS WEGLRDIIHC SRKYSGMIAN
KAPHDFQFVR KADENGPHSH RLYYLGMPYG SRENSLLYSE IPKKVRKEAL LVLSWKQMLD
HFQATPHQGA YSREEELLRE RKRLGAFGIT SYDYHDKTGL FLFQASNSLF YCQDGGSNGF
IQSAPVKPVE IKSHCSGTRM DPKICPGHPD FIAFINNNDL WIANIKTGEE RRLTYCHKGL
DNVKEDPKSA GVATFVIQEE FDRFTGYWWS PSAAEDPDGG RTLHLLYEEV DETEVEIIHV
PSPALEERKA DAYRYPRTGS KNPQATLKLA EIRTDHRGKI ISAQDKELVV PFNDLFPGTE
YIARAGWTID GKYGWAVLLD RSQRKLQLVL LPPALFIPVT EDSALRQESL EAVPSCVQPF
IIYEETTDVW INVHDIFYPF IQTTEDEFTF IWVNESKTGF SHLYKITSLL QPGCYRNFKC
TVKEEVTLTS GEWEVLARHG SKIWVNEGTK LVYFQGTRDT PLEHHLYVVS YESPGDVVRL
TKPGFSHSCS VSQNFDFFVS HYSNVSTPPC VHLYKLTSTE DDPLRVVPEF WASLMEPPKY
NPPEIFDFPG KSGFQLYGMV YKPHNLQPGR KHPTVLFVYG GPQVQLVNNS FKGMKYLRLN
TLASLGYAVV VIDGRGSCQR GLEFEGALKN KMGQVEIEDQ VEGLQYVAEK FNFVDLSRVA
IHGWSYGGFL SLMGLIQRPN IFKLAVAGAP VTVWMAYDTG YTERYMDVPE NNQQGYEEGS
VALHVDKLPS EPNRLLILHG FLDENVHFFH TNFLVSQIIR AGKPYQLQVY PNERHSIRCP
ESGEHYEIML LHFLQQYL
//
