ID A0A3Q2GRZ8_HORSE Unreviewed; 385 AA.
AC A0A3Q2GRZ8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=UBA domain containing 1 {ECO:0000313|Ensembl:ENSECAP00000023249.2};
GN Name=UBAC1 {ECO:0000313|VGNC:VGNC:24705};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000023249.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000023249.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000023249.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000023249.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000023249.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A3Q2GRZ8; -.
DR Ensembl; ENSECAT00000063179.2; ENSECAP00000023249.2; ENSECAG00000011717.4.
DR VGNC; VGNC:24705; UBAC1.
DR GeneTree; ENSGT00390000014658; -.
DR Proteomes; UP000002281; Chromosome 25.
DR Bgee; ENSECAG00000011717; Expressed in bone marrow and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2GRZ8; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd14303; UBA1_KPC2; 1.
DR CDD; cd14304; UBA2_KPC2; 1.
DR CDD; cd17066; Ubl_KPC2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 2.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041926; UBA1_UBAC1.
DR InterPro; IPR041927; UBA2_UBAC1.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46738; UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46738:SF1; UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00627; UBA; 2.
DR SMART; SM00165; UBA; 2.
DR SUPFAM; SSF46934; UBA-like; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50030; UBA; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 187..231
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 289..329
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 101..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 42691 MW; B4704F9E48F45D4B CRC64;
MFVQEEKIFA GKVLRLHICA FDGAEWLEEV TEDSTVEQLK ERCLKHCAHG SLEDPKSVTH
HKLIHAASER VLSDSKTILE ECIQDKDVLL LIKKRAPTPL PKMADVSAEE KKKQDQKAPD
RDAILQATAN LPSYNMDRAA VQTSTRDFQT ELRKILVSLI EVAQKLLALN PDAVELFKKA
NAMLDEDEDE RVDEAALRQL TEMGFPENRA VKALRLNHMS VPQAMEWLIE HAEDPTIDAP
LPGQASSGGA GAEAEAASEA AAGTSTGDEE PRDELTEIFK KIRRKREFRA DSRAVISLME
MGFDEKEVID ALRVNNNQQT AACEWLLGDR KPSPEELDKG IDPDSPLFQA ILDNPVVQLG
LTNPKTLLVP AHSCVFQLSP SSSSM
//
