ID A0A3Q2GT67_HORSE Unreviewed; 676 AA.
AC A0A3Q2GT67;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Protein tyrosine phosphatase receptor type E {ECO:0000313|Ensembl:ENSECAP00000023458.2};
GN Name=PTPRE {ECO:0000313|Ensembl:ENSECAP00000023458.2,
GN ECO:0000313|VGNC:VGNC:22030};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000023458.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000023458.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000023458.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000023458.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000023458.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2GT67; -.
DR Ensembl; ENSECAT00000044547.3; ENSECAP00000023458.2; ENSECAG00000008876.4.
DR VGNC; VGNC:22030; PTPRE.
DR GeneTree; ENSGT00940000156570; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000008876; Expressed in blood and 21 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2GT67; baseline.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14620; R-PTPc-E-1; 1.
DR CDD; cd14622; R-PTPc-E-2; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF499; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 111..370
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 290..361
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 402..665
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 581..656
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 77834 MW; 584E0469E3EF8458 CRC64;
MSTHEAVTSG CRLGRQRAAG GGGLQEAGGQ HGSAMSNRSS FSRLTWFRKQ RKAVVSANDK
KMPNGILEEQ EQQRVMLLSR SPSGPKKYFP IPVGHLEEEI RVRSADDCKR FREEFNSLPS
GHIQGTFEQA NKEENREKNR YPNILPNDHS RVTLSQLDGT PCSDYINASY IDGYKEKNKF
IAAQGPKQET VNDFWRMIWE QKSATIVMLT NLKERKEEKC YQYWPDQGCW TYGNIRVCVE
DCVILVDYTI RKFCIQSQLP DGCKAPRLVS QLHFTSWPDF GVPFTPIGML KFLKKVKTLN
PAHAGPVVVH CSAGVGRTGT FIVIDAMMDM MHTEQKVDVF EFVSRIRNQR PQMVQTDMQY
TFIYQALLEY YLYGDTELDV SSLEKHLQTL HSTATHFDKI GLEEEFRKLT NVRIMKENMR
TGNLPANMKK ARVIQIIPYD FNRVILSMKR GQEYTDYINA SFIDGYRQKD YFIATQGPLA
HTVEDFWRMV WEWKCHTIVM LTEVQEREQD KCYQYWPTEG SVTHGEITIE IKSDTLSEAI
SVRDFLVTFS QPMARQEEQT RVVRQFHFHG WPEIGIPAEG KGMIDLIAAV QKQQQQTGNH
PITVHCSAGA GRTGTFIALS NILERVKAEG LLDVFQAVKS LRLQRPHMVQ TLEQYEFCYK
VVQDFIDIFS DYANFK
//
