ID A0A3Q2GTD1_HORSE Unreviewed; 266 AA.
AC A0A3Q2GTD1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Prostaglandin reductase 2 {ECO:0000313|Ensembl:ENSECAP00000023846.2};
GN Name=PTGR2 {ECO:0000313|Ensembl:ENSECAP00000023846.2};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000023846.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000023846.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000023846.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000023846.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000023846.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2GTD1; -.
DR Ensembl; ENSECAT00000039632.2; ENSECAP00000023846.2; ENSECAG00000013284.3.
DR GeneTree; ENSGT00940000156793; -.
DR Proteomes; UP000002281; Chromosome 24.
DR Bgee; ENSECAG00000013284; Expressed in gluteus medius and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2GTD1; baseline.
DR GO; GO:0036132; F:13-prostaglandin reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR045010; MDR_fam.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR PANTHER; PTHR43205:SF5; PROSTAGLANDIN REDUCTASE 2; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2GTD1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 83..184
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 266 AA; 28604 MW; DC22029917DAFB1D CRC64;
MWDVASAWLD EQCHVCAQDS NQRNTGPPAA ECGVRELNHL ATGPAPGIGM PGLTSLIGIQ
EKGHITAGSN QTMVVSGAAG ACGSLAGQIG HIMGCSRVVG ICGTHEKCLF LTSELGFDAA
INYKKENVAE QLRELCPAGV DVYFDNVGGD ISDTVISQMN QSSHIILCGQ ISQYNKDVPY
PPPLPPAVEA IRKERNITRE RFLVLNYKDK FESGILQLSQ WFKEGKLKIK ETMINGLENM
GAAFQSMMTG GNTGKQIVCI SEETSL
//
