ID A0A3Q2GUI0_HORSE Unreviewed; 377 AA.
AC A0A3Q2GUI0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=ADAM metallopeptidase with thrombospondin type 1 motif 8 {ECO:0000313|Ensembl:ENSECAP00000024336.2};
GN Name=ADAMTS8 {ECO:0000313|Ensembl:ENSECAP00000024336.2,
GN ECO:0000313|VGNC:VGNC:15073};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000024336.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000024336.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024336.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000024336.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024336.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2GUI0; -.
DR Ensembl; ENSECAT00000059247.2; ENSECAP00000024336.2; ENSECAG00000014164.3.
DR VGNC; VGNC:15073; ADAMTS8.
DR GeneTree; ENSGT00940000156815; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000014164; Expressed in chorionic villus and 14 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2GUI0; baseline.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR013277; Pept_M12B_ADAM-TS8.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723:SF41; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8; 1.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 1.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01861; ADAMTS8.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50092; TSP1; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 108..177
FT /note="ADAMTS/ADAMTS-like cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF19236"
FT DOMAIN 180..297
FT /note="ADAMTS/ADAMTS-like Spacer 1"
FT /evidence="ECO:0000259|Pfam:PF05986"
FT DISULFID 26..63
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 30..68
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 41..53
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 377 AA; 41181 MW; A5B4C63DC9BCA4D2 CRC64;
MAAFYGADLQ TVVDGGWAPW GPWGECSRTC GGGVQFSHRE CKDPEPQNGG RYCLGRRAKY
QSCHTEECPP DGKSFREQQC EKYNAYNYTD VDGNPLQWVP KYAGVSPRDR CKLFCRARGR
SEFKVFEAKV IDGTLCGPET LAICVRGQCV KAGCDHVVDS PIKLDRCGVC GGKGNSCRKV
SGSLNPSSYG YNDIVTIPAG ATNIDVKQRS HPGVQNDGNY LALKTADGQY LLNGNLAISA
IEQDILVKGT ILKYSGSIAT LERLQSFRPL PEPLTVQLLT VPGEVFRPKV KYTFFVPNDV
DFSIQNSKER ATTNVIQPLI NAQWVLGDWS ECSSSCGAGW QRRTVECRDP NGQASATCNK
ALKPEDAKPC GSQPCPL
//
