ID A0A3Q2GUT5_HORSE Unreviewed; 944 AA.
AC A0A3Q2GUT5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 {ECO:0000313|Ensembl:ENSECAP00000024099.2};
GN Name=RAPGEF4 {ECO:0000313|Ensembl:ENSECAP00000024099.2,
GN ECO:0000313|VGNC:VGNC:22182};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000024099.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000024099.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024099.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000024099.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024099.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2GUT5; -.
DR Ensembl; ENSECAT00000052830.2; ENSECAP00000024099.2; ENSECAG00000017755.4.
DR VGNC; VGNC:22182; RAPGEF4.
DR GeneTree; ENSGT00940000156075; -.
DR Proteomes; UP000002281; Chromosome 18.
DR Bgee; ENSECAG00000017755; Expressed in prefrontal cortex and 18 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2GUT5; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 43..90
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 149..224
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 289..390
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 429..567
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 705..942
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 944 AA; 107921 MW; B0CF0F674EC72FD7 CRC64;
MVAAHAAHSS SSAEWIACLD KRPLERSSED VDIIFTRLKE VKAFEKFHPN LLHQICLCGY
YENLEKGITL FRQGDIGTNW YAVLAGSLDV KVSETSSHQK YRQYMAGLLA PPYGVMETGS
NNDRIPDKEN VPSEKILRAG KILRNAILSR APHMIRDRKY HLKTYRQCCV GTELVDWMLQ
QTPCAHSRTQ AVGMWQVLVE DGVLNHVDQE HHFQDKYLFY RFLDDEHEDA PLPTEEEKKE
CDEELQDTML LLSQMGPDAH MRMILRKPPG QRTVDDLEII YEELLHIKAL SHLSTTVKRE
LAGVLIFESH AKGGTVLFNQ GEEGTSWYII LKGSVNVVIY GKGVVCTLHE GDDFGKLALV
NDAPRAASIV LREDNCHFLR VDKEDFNRIL RDVEANTVRL KEHDQDVLVL EKVPAGNRAS
NQGNSQPQQK YTVMSGTPEK ILEHFLETIR LEPALNEATD SVLNDFVMMH CVFMPNIQLC
PALVAHYHAQ PSQGTEQEKM DYALNNKRRV IRLVLQWAAM YGDVLQEDDV AMAFLEEFYV
SVSDDARMIA ALKEQLPELE KIVKQISEDA KAPQKKHKVL LQQFNTGDER AQKRQPIRGS
DEVLFKVYCM DHTYTTIRVP VAASVKEVIS AVADKLGSGE GLIIVKMSSG GEKVVLKPND
VSVFTTLTIN GRLFACPREQ FDSLTPLPEQ EGPTVGTVGT FELMSSKDLA YQMTIYDWEL
FNCVHELELI YHTFGRHNFK KTTANLDLFL RRFNEIQFWV VTEICLCPQP SKRVQLLKKF
IKIAAHCKEY KNLNSFFAIV MGLSNVAVSR LALTWEKLPS KFKKFYAEFE SLMDPSRNHR
AYRLTIAKLD PPLIPFMPLL IKDMTFTHEG NKTFIDNLVN FEKMRMIANT ARTVRYCRSQ
PFNPDAAQAN KNHQDVRSYV RQLNVIDNQR TLSQMSHRLE PRRP
//
