ID A0A3Q2GW06_HORSE Unreviewed; 2310 AA.
AC A0A3Q2GW06;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Bromodomain and WD repeat domain containing 1 {ECO:0000313|Ensembl:ENSECAP00000024972.2};
GN Name=BRWD1 {ECO:0000313|Ensembl:ENSECAP00000024972.2,
GN ECO:0000313|VGNC:VGNC:15899};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000024972.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000024972.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024972.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000024972.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024972.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9796.ENSECAP00000024972; -.
DR PaxDb; 9796-ENSECAP00000024972; -.
DR Ensembl; ENSECAT00000049194.2; ENSECAP00000024972.2; ENSECAG00000022262.4.
DR VGNC; VGNC:15899; BRWD1.
DR GeneTree; ENSGT00950000183107; -.
DR InParanoid; A0A3Q2GW06; -.
DR OMA; DWTANAG; -.
DR OrthoDB; 24713at2759; -.
DR Proteomes; UP000002281; Chromosome 26.
DR Bgee; ENSECAG00000022262; Expressed in inner cell mass and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2GW06; baseline.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd05529; Bromo_WDR9_I_like; 1.
DR CDD; cd05496; Bromo_WDR9_II; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16266:SF17; BRWD3; 1.
DR PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 182..223
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 224..265
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 266..302
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 364..398
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 429..463
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 464..506
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1159..1229
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1313..1383
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 763..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1253..1281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1417..1579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1850..1918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1982..2063
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2114..2173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1431
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1449..1533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1549..1569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1682..1700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1768..1789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1878..1895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1993..2009
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2028..2043
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2128..2157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2310 AA; 262160 MW; E92F46757DD796E2 CRC64;
MAEPSPARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHS
RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH
TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR
RILGHLSAVY CVAFDRTGHR IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN
TMIAAGSCDK IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF
WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM YFLGFEAPEK
IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL EWRSILLDMA TRISGDLSSE
EERFMKPKVT MIAWNQNDSI VVTAVNDHVL KVWNSYTGQL LHNLLGHADE VFVLETHPFD
SRIMLSAGHD GSIFIWDITK GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL
LIFGFGCSKP YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH
PTKYQRLVPG RENSADEHLV PQLGYVATSD GEVIEQIISL QTNDNGERSP ESSVLDGMIR
ELQQQQDQRM GAGFRRLSLD IHSPPNIGLR RSGQVEGVRQ MHQNAPRSQI ATERDLQAWK
RRVVVPEVPL GIFRKLEDFR IEKGEEERNL YVIGRKRKTL QLSQKSDSVV MMSQSRQRTC
RRKYPNYGRR NLGRLELSSE NESSSSVRHE TSCDQSEGSC SSEEEEWKSD RRSESDSESS
SDSSSRYSDW TADAGINLQP PLRTSSRRRI TRFCSSSEDE MSTENLSPPK RRRKRKKENK
PKKENLRRVT PGELANMEHL YEFHPPVWIT DTTLRRSPFV PQMGDEVIYF RQGHEAYIEA
VRRNNIYELN PNKEPWRKMD LRDQELVKIV GIRYEVGPPT LCCLKLAFID PATGKLTDKS
FSIRYHDMPD VIDFLVLRQF YDEARQRNWQ SCDRFRSIID DAWWFGTVLS QEPYQRQYPD
SHFQCYIVRW DNTEIEKLSP WDMEPIPDNV DPPEELGASI SVTSDELEKL LYKPEDGEWG
QKSRDEECER IISGIDQLLN LDIAAAFAGP VDLCTYPKYC TVVAYPTDLY TIRMRLVNRF
YRRLSALIWE VRYIEHNART FNEPESVIAR SAKKITDQLL KFIKNQDCTN ISELSNTSEN
DEQNAEDLDD SDLPKTSSGR RRVHDWKKRS IKAVNYVESN WKKQCKELVN LIFQCEDSEP
FRQPVDLVEY PDYRDIIDTP MDFGTVRETL EAGNYDSPLE FCKDIRLIFS NAKAYTPNKR
SKIYSMTLRL SALFEEKMKK ISSDFKLGQK FNEKLRRSQR FKRRRKCNRV SQANRSIRNI
KQKRSKSQTK VIPELIGSPT QSTSSRAAYS ASHKMSASLS SGVTSGNSSD SAGSSERMRR
NRPVTLTNGS TLSESEMEDS LGTSSSSSAS HSSEESKESL RAREPSLRSG LARNSNLRVT
RTRAAQRKTG PVSLENGCGR KATRKRVYLS DSDNNSVETA ESLKARARNN RKVLRKCAAV
AANKIKLMSD VEENSSSESV CSGRKLPHRN ASAVARKKLL HNSEDDQSLK SEIEEEELKN
QNHASPLSTS HAAQSTGNES EDGDSESESD LRVARKNWHA NGYKSYTPAT SKTKFLKIES
SEEDSKSHDS DNGHDRTAGP STSGQKLKAE RISEEEEEAD SEPRKYIGRK YNASHKNATF
LKKAKIFSDS EDSESEEQDR EDGTCHKMET NQISGNLKCE PIAGSQCFSD HVSETDVDSD
DDKTKQKSSS STKDSTSQDH GQSRKVSRKR VCSSDSDSNS KVVKKSPKAK TGLQRIPRRC
ATTAASKIKL MSDVEDVSLE NVCTRSRNGR KRLHFASMTA KKIVSDSEGD GNCEVPNEQY
ACERKPPEAD SEGSTKSIHQ SLNGDSDSEG ILNSEHKNRH TTRHKTNVAP SKTKNSMIGS
SEEDSKSHIP GGEIGRKFSS ESTLVQKTTA ENNFEEELNY GLRRWNGRRL RTYGKAPFSK
TEVIRDSQEA AETEIKRKRL HPELENVKIS ETTGSSKCGP DTSPKSDSDL GSVTESDVDC
TDDTKTKKRK MRGKAKVVRK ESVPRDREPN TNMRTCMHNQ KDAVQMPSDT LKAKMVPEKV
PRRCATVAAN KIKIMSNLKE TISGPENVWI RKSSRKLPHR NASAAAKKKL LNVYKEDDTT
INSESEKELE DIHSKMFFFR RFRSWKEKAQ
//
