ID A0A3Q2GWH2_HORSE Unreviewed; 1141 AA.
AC A0A3Q2GWH2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Tight junction protein 2 {ECO:0000313|Ensembl:ENSECAP00000024821.3};
GN Name=TJP2 {ECO:0000313|Ensembl:ENSECAP00000024821.3,
GN ECO:0000313|VGNC:VGNC:24119};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000024821.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000024821.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024821.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000024821.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024821.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A3Q2GWH2; -.
DR Ensembl; ENSECAT00000048784.3; ENSECAP00000024821.3; ENSECAG00000016742.4.
DR VGNC; VGNC:24119; TJP2.
DR GeneTree; ENSGT00940000158634; -.
DR Proteomes; UP000002281; Chromosome 23.
DR Bgee; ENSECAG00000016742; Expressed in trophoblast and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2GWH2; baseline.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12027; SH3_ZO-2; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR005417; ZO.
DR InterPro; IPR005419; ZO-2.
DR InterPro; IPR035598; ZO-2_SH3.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR PANTHER; PTHR13865:SF26; TIGHT JUNCTION PROTEIN ZO-2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01597; ZONOCCLUDNS.
DR PRINTS; PR01599; ZONOCCLUDNS2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q2GWH2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 37..124
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 301..379
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 497..578
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 592..657
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 762..864
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 151..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 968..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..929
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1106..1122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 128491 MW; E390B48B6615A08C CRC64;
MKTAQVLQRM WIQAVKKLRR WKGRAPGMEE LIWEQYTVTL QKDSKRGFGI AVSGGRDNPH
FENGETSIVI SDVLAGGPAD GLLQENDRVV MVNGTPMEDV LHSFAVQQLR KSGKIAAIVV
KRPRRVQLAP PQGSRPLDED DRAFEVMDDF DGRSAHSGYS ERSRPSSRGG RSRSLEDSPE
RGHPHERARS RERDRSRGRS LERGLDHDDY GRARERSRGR SLERGLDHDD YERARERSRG
WGIDEAYKRA YSPEVEYSRR AQPDARYEGS RSRSREHLRS RSPSPDPRGR PDRLDADRPI
GVLLMKSKAN EEYGLRLGSQ IFIKEMTRTG LASKDGNLHE GDIILKINGT VTENMSLTDA
RKLIEKSRGK LQLVVLRDSK QTLINIPSLN DSDSEIEDIS EIESNRSFSP EERQQQYSDY
DYHSSNEKLK ERPSSREDMQ NRWSRMGATP TPFKSSGDVE TSKEPRHQEE PPAPQPKPAP
RTFSRPSPED EAIYGPNTKM VRFKKGDSVG LRLAGGNDVG IFVAGIQEGT SAEQEGLQEG
DQILKVNTQD FRGLVREDAV LYLLEIPKGE VVTILAQSRA DVYRDILACG RGDSFFIRSH
FECEKETPQS LAFTRGEVFR VVDTLYDGKL GHWLAVRIGN ELEKGLIPNK SRAEQMASVQ
NAQRDNAGDR ADFWRMRGQR SGAKKNLRKS REDLTAAVSV STKFPAYERV LLREAGFKRP
VVLFGPIADI ALEKLANELP DLFQTAKTEP KDAGSEKSSG VVRLNTVRQI IEQDKHALLD
VTPRAVDLLN YTQWFPIVIF FNPDSRQGVK TMRQRLNPTS NKSSRKLYDQ ANKLKKTCAH
LFTATINLNS ANDGWFGSLK DTIQQQQGEA VWVSEGKMEG MDDDPEDRMS YLTAMGADYL
SCDSRLISDF EDTDGEGGAY TDNELDEPAE EPLVSSITRS SEPVQHEEAK TQNREEFFDF
SRSYEYNSNP SAVTGNEVPG ASPKGGPPPV AAKPALGRSI LKPTTPVPPP ESEEVGEAGE
GQDSAPKSVL GKVKIFEKMD HKARLQRMQE LQEAQNARIE IAQKHPDIYA VPIKTHKPDP
GPPQYTSSRT PEPQKVPSRL YQDPRGSYES DAEEEEYRQQ LSEQSKRGYY SQPSRYRDTE
L
//
