ID A0A3Q2GWV2_HORSE Unreviewed; 930 AA.
AC A0A3Q2GWV2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Sterile alpha motif domain containing 11 {ECO:0000313|Ensembl:ENSECAP00000024994.2};
GN Name=SAMD11 {ECO:0000313|VGNC:VGNC:50759};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000024994.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000024994.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024994.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000024994.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000024994.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2GWV2; -.
DR Ensembl; ENSECAT00000065601.3; ENSECAP00000024994.2; ENSECAG00000007281.4.
DR VGNC; VGNC:50759; SAMD11.
DR GeneTree; ENSGT00940000160830; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000007281; Expressed in retina and 19 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2GWV2; baseline.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR000770; SAND_dom.
DR PANTHER; PTHR10417; GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN; 1.
DR PANTHER; PTHR10417:SF12; STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 11 ISOFORM X2; 1.
DR Pfam; PF01342; SAND; 1.
DR SMART; SM00258; SAND; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
DR PROSITE; PS50864; SAND; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 106..186
FT /note="SAND"
FT /evidence="ECO:0000259|PROSITE:PS50864"
FT REGION 225..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..563
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 930 AA; 99250 MW; 8F3E8B1E7ACDC228 CRC64;
MPAVKKELPG REDLALALAT FHPTLAALPL PPLPGYLTPL PAAAALPPAA SLPAATAGYE
ALLAPPLRAP RAYLSLHEAA PHLHLPRDPL ALERFSATAA AAPDFQPLLD NGEPCIEVEC
GANRALLYVR KLCQGSKGPS IRHRGEWLTP NEFQFVSGRE TAKDWKRSIR HKGKSLKTLM
SKGILQVHPP ICDCPGCRIS SPVNRGRLAD KRTVAPSPVR ILKKELTPSF SVSDGDSDGS
GPACGRRPGL KQEDDPHVRI MKRRVHTHWD VNISFRETSC SQDSDLSTLI SSVHRSRQLV
MPEHQSRCEF QRGGVEVGLG ATETLLLPEL GPSMAPEDHY RRLVSTLSEA STFEDPQRLY
HLGLPSHDLL RVRQEVAAAA VRSPSGLEVH LPSSTAGQRR KQGLAQHREG TTPAGAPSFS
ERELSQPPPL LSPQNAPHIA LGPHLRPPFL GVPSALCQTP GYGFLPPAQA EMLARQQELL
RKQNLARLEM SAELLRQKEL ESAHRPQLLA PEASLRPPEG TEELQRRGAM LVLRHSSAPL
LALPPQGPPG PGPPTPPREP ARRAPGKGGP SLASARPSES KETTGTGLWA PDGSEDEPPK
DSDGEDPEMV AAGGRGPTPG QAPAGGASSE GKGLLSGSML PPPLPLGLPY AVSPYFHTGT
MGGLFTDGEA TAPEDVSKWT VEDVCSFVGG LSGCGEYAPV RGHLPKMVFS SPSASSHPRF
LFENWGGDGH RGMLLLLLCH TRVSAFNTGI CLAKQVSFFW LNVFPVSCTN SSLILLSGKP
GVTPGHPAFP GLQGTQQVGK HCSWPQAHIT SIQVFREQGI DGETLPLLTE EHLLTTMGLK
LGPALKIRAQ VARRLGRVFY MASCPVALPL QPPPLRAPEQ ELMPGEQPLS PATAPSPCGG
EHSPAGASPK QENGTLALLP GPVDPSQPLC
//
