ID A0A3Q2H1D9_HORSE Unreviewed; 604 AA.
AC A0A3Q2H1D9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Nectin cell adhesion molecule 2 {ECO:0000313|Ensembl:ENSECAP00000026852.3};
GN Name=NECTIN2 {ECO:0000313|Ensembl:ENSECAP00000026852.3,
GN ECO:0000313|VGNC:VGNC:49528};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000026852.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000026852.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000026852.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000026852.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000026852.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q2H1D9; -.
DR STRING; 9796.ENSECAP00000026852; -.
DR PaxDb; 9796-ENSECAP00000026852; -.
DR Ensembl; ENSECAT00000043816.3; ENSECAP00000026852.3; ENSECAG00000009306.4.
DR VGNC; VGNC:49528; NECTIN2.
DR GeneTree; ENSGT00940000161167; -.
DR InParanoid; A0A3Q2H1D9; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000009306; Expressed in trophoblast and 23 other cell types or tissues.
DR GO; GO:0043296; C:apical junction complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR GO; GO:0001675; P:acrosome assembly; IBA:GO_Central.
DR GO; GO:0046814; P:coreceptor-mediated virion attachment to host cell; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0051654; P:establishment of mitochondrion localization; IBA:GO_Central.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR GO; GO:0002891; P:positive regulation of immunoglobulin mediated immune response; IBA:GO_Central.
DR GO; GO:0033005; P:positive regulation of mast cell activation; IBA:GO_Central.
DR GO; GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; IBA:GO_Central.
DR GO; GO:0050862; P:positive regulation of T cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0046596; P:regulation of viral entry into host cell; IBA:GO_Central.
DR GO; GO:0042271; P:susceptibility to natural killer cell mediated cytotoxicity; IBA:GO_Central.
DR GO; GO:0060370; P:susceptibility to T cell mediated cytotoxicity; IBA:GO_Central.
DR CDD; cd20930; Ig3_Nectin-5_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR47387; NECTIN-2; 1.
DR PANTHER; PTHR47387:SF1; NECTIN-2; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..604
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040210352"
FT TRANSMEM 362..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..142
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 164..256
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 263..348
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 392..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..540
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 64882 MW; A67EE2E4B04F5F2C CRC64;
MARAAALPPS RSLRTLPLLP LLLLLLRETG AQDVQVRVLP EVRGHLGGTV ELPCHLLPPA
SEVQVSQVTW MRMDAAGISS NVAVFHPLYG PSFPSPKPGK ERLSFVTARQ SPGAGQGAKM
ELRDATLALG GLTVEDEGNY TCEFATFPQG TGRGVTWLRA IAQPQNRIEK QEVPLSLEPV
PVARCVSTGG RPPARISWLS PLDGEARESQ VSGSVPGTVT VTSRFTLVPL GRADGVEVIC
KVEHESFKEP DLLSVSLSVR YPPEVSISGY DDNWYLGRSE ATLSCDVRSN PEPTGYDWST
TSGTLPASAV AQGPQLIIHS VDKLVNTTFI CTVTNAVGTG RAEQVVLVRD TPRASTRDVG
PVVWGAVGGT LLVLLLLAGG SLAFILLRGR RRRKSPGGGE DGGRGASYDA KTQVFGNGGP
VYRTPVAPGP PGPDGKDEED EEEDEEKEEK AEKDLMLPPP PVLEDDMESQ LDGSLISRRA
RLPTQQAQGP RVASLGASLL PSLPPLWLPR ASSSAGSSRR SRGCRGQRRR MTRRGLPRTS
HPPQRRSWRS QRCPPSYSLW GPRSTAHSRP PTLMLVSHAL SRNCLDTMSC PPWKSGRGPC
SQGP
//
