ID A0A3Q2H207_HORSE Unreviewed; 1256 AA.
AC A0A3Q2H207;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Par-3 family cell polarity regulator {ECO:0000313|Ensembl:ENSECAP00000027535.2};
GN Name=PARD3 {ECO:0000313|Ensembl:ENSECAP00000027535.2,
GN ECO:0000313|VGNC:VGNC:21160};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000027535.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000027535.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027535.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000027535.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027535.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000033585.3; ENSECAP00000027535.2; ENSECAG00000016619.4.
DR VGNC; VGNC:21160; PARD3.
DR GeneTree; ENSGT00950000183214; -.
DR Proteomes; UP000002281; Chromosome 29.
DR Bgee; ENSECAG00000016619; Expressed in articular cartilage of joint and 21 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2H207; baseline.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF10; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF00595; PDZ; 2.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 199..246
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 363..448
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 492..567
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 948..975
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 15..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..340
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..933
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1077
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1256 AA; 140191 MW; 983D41C6AF197745 CRC64;
MLVAVFDEQD PHHGGDGTSA SSTGTQSPEI FGSELGTNSV SAFQPYQAAS EIEVTPSVLR
ANMPLHVRRS SDPALVGLST SLSDSNFSSE EPSRKNPTRW STTAGFLKQN TAGSPKACDR
KKDENYRSLP RDTSNWSNQF QRDNARSSLS ASHPMVDKWL EKQEQDEDGT EEDNSRVEPV
GHADTGLENI PNFSLETLGL LVKRLEKGGK AEQENLFHEN DCIVRINDGD LRNRRFEQAQ
HMFRQAMRTP IIWFHVVPAA KKEQYEQLSQ SENTYSCSRF SPDSQYADNR SVNSAGLQAL
QRAPRPARPA HPADQADPHP RLLPHSTHPP GKPPSAPAPA PQTVFSTSVS SGYNTKKIGK
RLTIQLKKGT EGLGFSITSR DVTIGGSAPI YVKNILPRGA AIQDGRLKAG DRLIEVNGVD
IAGQSQEEVV SLLRSTKMEG TVSLLVFRQE DAFHPRELNA EPSQMQIPKE TKAEDEDIVL
TPDGTREFLT FEVPLNDSGS AGLGVSVKGN RSKENHADLG IFVKSIINGG AASKDGRLRV
NDQLIAVNGE SLLGKTNQDA METLRRSMST EGNKRGMIQL IVARRISKCN ELKSPGSPSG
PELPIETVLD DRERRISHSL YSGIEGLDES PTRNAALSRI MGKYQLSPTV NMPQDDTVII
EDDRLPVLPP HLSDQSSSSS HDDVGFVTTE TGTWAKAVVT DSADCSLSPD VDPVLAFQRE
GFGRQSMSEK RTKQFSDASQ LDFVKTRKSK SMDLGIADET KLNTVDDQKA GSPSRDVGPS
LGLKKSSSLE SLQTAVAEVT LNGDIPFHRP RPRIIRGRGC NESFRAAIDK SYDKPSVDDD
DEGMETLEED TEESSRSGRE SVSTASDQPS HSLERQMNGN QEKGDKTERR KDKTGKEKKK
EREKEKEKMK AKKGMLKGLG DMFRFGKHRK DDKIEKTGKI KIQDSLTSEE ERIRMKQEQE
RIQAKTREFR ERQARERDYA EIQDFHRTFG CDDELVYGGI SSYEGSMALS ARPQSPREGH
MMDALYAQVK KPRNSKPSPA DGNRSTPSNH DRIQRLRQEF QQAKQDEDVE DRRRTYSFEQ
PWPSSRPAAQ SGRHSVSVEV QMQRQRQEER ESFQQAQRQY SSLPRQSRKN ASSVSQDSWE
QSYSPGEGFQ SAKENPRYSS YQGSRNGYLG GHGFNARVML ETQELLRQEQ RRKEQQMKKQ
PPPPEGLTNY DSYKKVQDPN YAPAKGPFRQ DVPPSPSQVA RLNRLQTPEK GRPFYS
//
