ID A0A3Q2H3F5_HORSE Unreviewed; 1077 AA.
AC A0A3Q2H3F5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=RIMS binding protein 2 {ECO:0000313|Ensembl:ENSECAP00000027531.2};
GN Name=RIMBP2 {ECO:0000313|Ensembl:ENSECAP00000027531.2,
GN ECO:0000313|VGNC:VGNC:50965};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000027531.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000027531.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027531.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000027531.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027531.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIMBP family.
CC {ECO:0000256|ARBA:ARBA00010749}.
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DR AlphaFoldDB; A0A3Q2H3F5; -.
DR Ensembl; ENSECAT00000056877.2; ENSECAP00000027531.2; ENSECAG00000009720.4.
DR VGNC; VGNC:50965; RIMBP2.
DR GeneTree; ENSGT00950000183203; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000009720; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR CDD; cd00063; FN3; 3.
DR CDD; cd12014; SH3_RIM-BP_1; 1.
DR CDD; cd12012; SH3_RIM-BP_2; 1.
DR CDD; cd12013; SH3_RIM-BP_3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR035753; RIM-BP_SH3_2.
DR InterPro; IPR035755; RIM-BP_SH3_3.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; RIM BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14234:SF18; RIMS-BINDING PROTEIN 2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50002; SH3; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 184..251
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 506..607
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 873..941
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 977..1044
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 142..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..74
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 674..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1077 AA; 118514 MW; D8D1362F35669E34 CRC64;
MREAAERRQQ LELEHEQALA VLNAKQQEID LLQKAQVEAK KEHEGAVQLL ESKVRELEEK
CRTQSEQFSL LSRDLEKFRQ HAGKIDLLGG SSVASLDVPT SPSKPFPPYM NGLAPSISKG
QESSIGSRAA IGEYIRPLPL PRDKPEPLSV KPTFLSRSSS PRCRFEPDMD NERNSNASKQ
RYSGKVHLCV ARYSYNPFDG PNENPEAELP LTAGKYLYVY GDMDEDGFYE GELLDGQRGL
VPSNFVDFVQ DNESRLASAL GNEQDQNFIN HSSFGVEGES ILDLHSPTQT DTGITDNGAG
TLDMNIDDIG EDIVPYPRKI TLIKQLAKSV IVGWEPPAVP PGWGTVSSYN VLVDKETRLS
LTLGGRTKAL IEKLNMAACT YRISVQCMTS RGSSDELQCT LLVGKDVVVA PSHLRVDNIT
QISAQLSWLP TNSNYSHVIF LNEEEFDIVK AARYKYQFFN LRPNMAYKVK VLAKPHQMPW
QLPLEQREKQ EAFVEFSTLP AGPPAPPQDV TVQAGASSAT VQVSWRPPTL TTTGLSNGAN
VTGYGVYAKG HRVAEVISPT ADSTAVELVR LRSLEAKGVT VRTLSAQGES IDSAVAAIPA
DLLVPPTPHP RTAPTPKPLA SAGAPDTKDE HLGPHVKVDE AWEQSRVPAP AHGHMLEPPG
LQGPGPGRRS PSPSRILPQP QGTPVSTSVA KAMAREAAQR VAESSRLEKR SIFLERSSGQ
YTNSDEEDGY DSPDVKRRGA SVDDFLKGSE LGKPPHCCHG DEYHTESSRG SDLSDIMEED
EEELYSEMQL EDGGRRRPSG TSHNALKILG NLVLAGRATE RADHGGRRFA HGGAGPQRSR
PVMVPSIDEY GGRDRLSPDF YEESETDPGA EELPARIFVA LFDYDPLTMS PNPDAAEEEL
PFKEGQIIKV YGDKDADGFY RGETCARLGL IPCNMVSEIQ ADDEEMMDQL LRQGFLPLNT
PVEKIERNRR SGRQHSVSTR RMVALYDYDP RESSPNIDVE AELTFCTGDI ITVFGEIDED
GFYYGELNGQ KGLVPSNFLE EVPDDVEVYL SDAPSHYSQD TPMRSKAKRG FHDSSTS
//
