ID A0A3Q2H410_HORSE Unreviewed; 478 AA.
AC A0A3Q2H410;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=RAB3A interacting protein like 1 {ECO:0000313|Ensembl:ENSECAP00000027988.2};
GN Name=RAB3IL1 {ECO:0000313|Ensembl:ENSECAP00000027988.2,
GN ECO:0000313|VGNC:VGNC:58228};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000027988.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000027988.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027988.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000027988.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000027988.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SEC2 family.
CC {ECO:0000256|ARBA:ARBA00025794}.
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DR AlphaFoldDB; A0A3Q2H410; -.
DR Ensembl; ENSECAT00000040997.3; ENSECAP00000027988.2; ENSECAG00000006755.4.
DR VGNC; VGNC:58228; RAB3IL1.
DR GeneTree; ENSGT00940000159102; -.
DR Proteomes; UP000002281; Chromosome 12.
DR Bgee; ENSECAG00000006755; Expressed in bone marrow and 21 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.5.4880; -; 1.
DR InterPro; IPR040351; RAB3IL/RAB3IP/Sec2.
DR InterPro; IPR009449; Sec2_N.
DR PANTHER; PTHR14430:SF5; GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB-3A; 1.
DR PANTHER; PTHR14430; RABIN3-RELATED; 1.
DR Pfam; PF06428; Sec2p; 1.
DR SUPFAM; SSF144284; Sec2 N-terminal region; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 138..208
FT /note="GDP/GTP exchange factor Sec2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06428"
FT REGION 39..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 123..207
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 43..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 52710 MW; 146F6C67FAB8586E CRC64;
MDAPEKPSWC PARATCPVFL AMSSGTVCDA PTGLGLALEG NLREEPWDTE SQPHLDEGHP
PPLEAAPVSW KSVGPCKSLR EPPGGLAEAS VGEEAQGEED PAAAQLDVLR LRSSSMEIRE
KGSEFLKEEL HKAQKELKLK DKECERLSKV REQLEQELEE LTASLFEEAH KMVREANMKQ
AASEKQLKEA RGKIDMLQAE VTALKTLVIT STPASPNREL HPQLLSPTKA GPRKGHLRHK
STSSTLCPTV CPTAGHTLPP DKEGKEPGLP PLLSLLLCVV PSKVVHLTYE PAWQLLPGEL
PVAPTSATCL SFSRQVDTVL FAEFQAWRES PTLDKTCPFL ERVYREDVGP CLDFTMQELS
VLVRAAVEDN TLTIEPVASQ TLPAMKVAAV ECGSTNTCAL SGLARACRHR IRLGDSEGHY
YISPSSRARI TAVCNFFTYI RYIQQGLVRQ DAEPMFWEIM RLRKEMSLAK LGFFPQEA
//
