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Database: UniProt
Entry: A0A3Q2H4E1_HORSE
LinkDB: A0A3Q2H4E1_HORSE
Original site: A0A3Q2H4E1_HORSE 
ID   A0A3Q2H4E1_HORSE        Unreviewed;      1213 AA.
AC   A0A3Q2H4E1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSECAP00000028569.1};
GN   Name=EVC2 {ECO:0000313|Ensembl:ENSECAP00000028569.1,
GN   ECO:0000313|VGNC:VGNC:17710};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000028569.1, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000028569.1, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000028569.1,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000028569.1}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000028569.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
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DR   AlphaFoldDB; A0A3Q2H4E1; -.
DR   Ensembl; ENSECAT00000040610.2; ENSECAP00000028569.1; ENSECAG00000021897.3.
DR   VGNC; VGNC:17710; EVC2.
DR   GeneTree; ENSGT00940000154127; -.
DR   Proteomes; UP000002281; Chromosome 3.
DR   Bgee; ENSECAG00000021897; Expressed in articular cartilage of joint and 18 other cell types or tissues.
DR   ExpressionAtlas; A0A3Q2H4E1; baseline.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR   InterPro; IPR022076; Limbin.
DR   InterPro; IPR026501; Limbin/EVC.
DR   PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR   PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR   Pfam; PF12297; EVC2_like; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        281..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          34..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          696..723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1066..1087
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          444..474
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1213 AA;  136662 MW;  CC6ACE6882C35D32 CRC64;
     MGLAGPLGRA TWVLAGGLLA AALALLTGPG GRGRLPAGPS PFRRPLGAQP PPDPHERTAQ
     DLPHVIQPEV ESSHFHTAVA APFGMNVNRT VEVFNPLPTS AASRGPWAQS VFASLLSWPK
     RTLFKRESPL THHLYGDISR DIQGTFENGV VFQKCAVVSG QSALQTAQVR LLVNNTKTPG
     AANLSDLLLL DNITGLTVSG STGNKTSEGF QAFRRKFLQV GDSFSVNYTA SLEARDVGSG
     EILMLPARLT FQSSSPNRTQ LKALFTIIAE EKIKILPDHG LHAAGFFTAF IGSLVLTWVA
     LFFLVRCECL RGSRLGRRQV QHHESRLEHS QFISADGVNE DLALNDQMVD ILSSEDPGSM
     LQALEELEIA TLNRADSDLE ACRTQISKDI IALLLKNLTS SGHLSPQAER RMAAVFKKQF
     LLLEKEIQEE YDRKMVALTA ECDLETRKKT ENQYQREMAA MEEAEELLKR VSERENVEEL
     MDFFQASKRY HLSKRFGHRE CLVQNMQSSE TRVQGLLSAA AAQLSLLIQK HERAGYLEEH
     QMEVLLERAQ TEVFSIKQKL DNDLKREKRK LHQKLIIKRR REMLQKHKEQ RKEQLSVGEA
     FRAAEDLGQY LGQWRSLMAE HSTALEELQE HLDQAALDDL RALTLSLSER AAEELRRLQN
     SVMTQELLKR SVPWLFLQQI LEEHGKDMAA RAEQLEAEER DRGQEGVQSV RQRLKDDAPE
     ASTDEQVELR RWERFIFLKL SSSAFSLSEE ELLRMRQEVH GCFAQMDRSL ALPKIRARVL
     LQRLQTAWRE AEFLKLDQAL AAPELQQQSK ARKPRSKSKS KIELLKKCLE DKIQLFDEQA
     PEDLAEKVRG ELLRERVQQL EAQEGRFAES LVSLQFQKAA RMAKTLWAYT ALLSIQDLLL
     EELSASETLT KAACAQILES HSPELQELER KLEDELALQE AAQLQQALAS QQQQAGAGPG
     LLHEPEEADS ERQVSAVLRR ALSRSQKLLE QHEQSWREEQ ENSVVLEDLL ENMETDTFVT
     LYSQELRLAS YLAKLTMVPG ATLRRLLSVA LPAASQPELL AMLDSVSQKH HDHAAESDGG
     GEQADLGRRR KHQGWWQALE SKLRGELTSR GLEKMLWAHA RKESILKKTC PPLRERMTFS
     GKGSWPHLSL ESVGELAPVP VVGADTIDLL DTGEKIFIFR NPKEPEISLH FAPRKKKKNF
     LNAKKASWAL GLD
//
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