ID A0A3Q2H4E1_HORSE Unreviewed; 1213 AA.
AC A0A3Q2H4E1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSECAP00000028569.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSECAP00000028569.1,
GN ECO:0000313|VGNC:VGNC:17710};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000028569.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000028569.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000028569.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000028569.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000028569.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR AlphaFoldDB; A0A3Q2H4E1; -.
DR Ensembl; ENSECAT00000040610.2; ENSECAP00000028569.1; ENSECAG00000021897.3.
DR VGNC; VGNC:17710; EVC2.
DR GeneTree; ENSGT00940000154127; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000021897; Expressed in articular cartilage of joint and 18 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2H4E1; baseline.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 34..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 444..474
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1213 AA; 136662 MW; CC6ACE6882C35D32 CRC64;
MGLAGPLGRA TWVLAGGLLA AALALLTGPG GRGRLPAGPS PFRRPLGAQP PPDPHERTAQ
DLPHVIQPEV ESSHFHTAVA APFGMNVNRT VEVFNPLPTS AASRGPWAQS VFASLLSWPK
RTLFKRESPL THHLYGDISR DIQGTFENGV VFQKCAVVSG QSALQTAQVR LLVNNTKTPG
AANLSDLLLL DNITGLTVSG STGNKTSEGF QAFRRKFLQV GDSFSVNYTA SLEARDVGSG
EILMLPARLT FQSSSPNRTQ LKALFTIIAE EKIKILPDHG LHAAGFFTAF IGSLVLTWVA
LFFLVRCECL RGSRLGRRQV QHHESRLEHS QFISADGVNE DLALNDQMVD ILSSEDPGSM
LQALEELEIA TLNRADSDLE ACRTQISKDI IALLLKNLTS SGHLSPQAER RMAAVFKKQF
LLLEKEIQEE YDRKMVALTA ECDLETRKKT ENQYQREMAA MEEAEELLKR VSERENVEEL
MDFFQASKRY HLSKRFGHRE CLVQNMQSSE TRVQGLLSAA AAQLSLLIQK HERAGYLEEH
QMEVLLERAQ TEVFSIKQKL DNDLKREKRK LHQKLIIKRR REMLQKHKEQ RKEQLSVGEA
FRAAEDLGQY LGQWRSLMAE HSTALEELQE HLDQAALDDL RALTLSLSER AAEELRRLQN
SVMTQELLKR SVPWLFLQQI LEEHGKDMAA RAEQLEAEER DRGQEGVQSV RQRLKDDAPE
ASTDEQVELR RWERFIFLKL SSSAFSLSEE ELLRMRQEVH GCFAQMDRSL ALPKIRARVL
LQRLQTAWRE AEFLKLDQAL AAPELQQQSK ARKPRSKSKS KIELLKKCLE DKIQLFDEQA
PEDLAEKVRG ELLRERVQQL EAQEGRFAES LVSLQFQKAA RMAKTLWAYT ALLSIQDLLL
EELSASETLT KAACAQILES HSPELQELER KLEDELALQE AAQLQQALAS QQQQAGAGPG
LLHEPEEADS ERQVSAVLRR ALSRSQKLLE QHEQSWREEQ ENSVVLEDLL ENMETDTFVT
LYSQELRLAS YLAKLTMVPG ATLRRLLSVA LPAASQPELL AMLDSVSQKH HDHAAESDGG
GEQADLGRRR KHQGWWQALE SKLRGELTSR GLEKMLWAHA RKESILKKTC PPLRERMTFS
GKGSWPHLSL ESVGELAPVP VVGADTIDLL DTGEKIFIFR NPKEPEISLH FAPRKKKKNF
LNAKKASWAL GLD
//