ID A0A3Q2H4R3_HORSE Unreviewed; 610 AA.
AC A0A3Q2H4R3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Double-stranded RNA-binding protein Staufen homolog 2 {ECO:0000256|ARBA:ARBA00024122};
GN Name=STAU2 {ECO:0000313|Ensembl:ENSECAP00000028729.1,
GN ECO:0000313|VGNC:VGNC:23670};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000028729.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000028729.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000028729.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000028729.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000028729.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2H4R3; -.
DR Ensembl; ENSECAT00000063627.2; ENSECAP00000028729.1; ENSECAG00000000260.4.
DR VGNC; VGNC:23670; STAU2.
DR GeneTree; ENSGT00940000154977; -.
DR OMA; PQNITEM; -.
DR Proteomes; UP000002281; Chromosome 9.
DR Bgee; ENSECAG00000000260; Expressed in brainstem and 23 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd19880; DSRM_STAU2_rpt1; 1.
DR CDD; cd19882; DSRM_STAU2_rpt2; 1.
DR CDD; cd19884; DSRM_STAU2_rpt3; 1.
DR CDD; cd19886; DSRM_STAU2_rpt4; 1.
DR Gene3D; 3.30.160.20; -; 5.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR044476; STAU2_DSRM_1.
DR InterPro; IPR044464; STAU2_DSRM_2.
DR InterPro; IPR044473; STAU2_DSRM_3.
DR InterPro; IPR044474; STAU2_DSRM_4.
DR InterPro; IPR032478; Staufen_C.
DR PANTHER; PTHR46054:SF1; DOUBLE-STRANDED RNA-BINDING PROTEIN STAUFEN HOMOLOG 2; 1.
DR PANTHER; PTHR46054; MATERNAL EFFECT PROTEIN STAUFEN; 1.
DR Pfam; PF00035; dsrm; 4.
DR Pfam; PF16482; Staufen_C; 1.
DR SMART; SM00358; DSRM; 4.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 4.
DR PROSITE; PS50137; DS_RBD; 4.
PE 4: Predicted;
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 27..94
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 114..200
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 226..293
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 326..394
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 90..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 610 AA; 67321 MW; 82224A9BAB284035 CRC64;
METDPSVERL ALAASLQDKM ANPKEKTPMC LVNELARFNR VQPQYKLLRE RGPAHSKMFS
VQLSLGEQTW ESEGSSIKKA QQAVANKALT ESTLPKPVQK PPKSNVNNNP GSITPTVELN
GLAMKRGEPA IYRPLDPKPF PNYRANYNFR GMYNQRYHCP MPKIFYVQLT VGNNEFFGEG
KTRQAARHNA AMKALQALQN EPIPEKSPQN GESGKEMDDD KDANKSEISL VFEIALKRNM
PVSFEVIKES GPPHMKSFVT RVSVGEFSAE GEGNSKKLSK KRAATTVLQE LKKLPPLPVV
EKPKLFFKKR PKTIVKAGPE YGQGMNPISR LAQIQQAKKE KEPDYVLLSE RGMPRRREFV
MQVKVGNEVA TGTGPNKKIA KKNAAEAMLL QLGYKASTSL QDQLDKTGEN KGWSGPKAGF
PEPTSNTPKG ILHLSPDVYQ EMEASRHKVI SGTTLGYLSP KDMNQPSSSF FSISPTSNSS
ATIARELLMN GTSPAEAVGL KGSSPTPPCS PVQPSKQLEY LARIQGFQVH YCDRQSGREC
VTCLTLAPVQ MTFHAIGSSI EASHDQCPCV ERITEHSIMT DLLKHMINCP TQTRPRKTFL
GAALSSSGRL
//
