ID A0A3Q2H5T4_HORSE Unreviewed; 863 AA.
AC A0A3Q2H5T4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rho guanine nucleotide exchange factor 33 {ECO:0000313|Ensembl:ENSECAP00000028471.3};
GN Name=ARHGEF33 {ECO:0000313|Ensembl:ENSECAP00000028471.3,
GN ECO:0000313|VGNC:VGNC:58913};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000028471.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000028471.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000028471.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000028471.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000028471.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2H5T4; -.
DR Ensembl; ENSECAT00000044184.3; ENSECAP00000028471.3; ENSECAG00000018712.4.
DR VGNC; VGNC:58913; ARHGEF33.
DR GeneTree; ENSGT00940000162759; -.
DR Proteomes; UP000002281; Chromosome 15.
DR Bgee; ENSECAG00000018712; Expressed in cerebellum and 14 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2H5T4; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR042849; ARHGEF33.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR46944; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR PANTHER; PTHR46944:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 265..440
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 863 AA; 97013 MW; FB1928650124C3F8 CRC64;
MEKTKTKQGE NEHIPMNNPS TQIYQLQALA SELKTGFTEA MQELSRIQHG EYALEEKVKS
CRCSMEEKVT EMKNSLNYFK EELSNAMSMI QAITSKQEEM QQKIEQLQQE KRRESRKVKA
KKTQKEEHTS PAGPPQAQGS PFRSINIPEP VLPSEDFTNL LPSQAYEKAQ ESRSMHVGDS
NVKGMMGPGM NPTTPEAEEN LKSCLSADIQ SKGHLPSGVW RQLKDGKEWG EEYVTKDHPD
KLKETSQGRH SSLENVLCET SLAAKRQTVA LELLESERKY VINISLILKI KATFQGSDGK
RNSKERSLFP GSLRYLVQQH LDLLHALQER VLKWPRQGVL GDLFLKLTND ENNFLDYYVA
YLRDLPECIS LVHVVVLKEG DEDIKSDIYT LFFHIVQRIP EYLIHLQNVL KFTEQEHPDY
YLLLVCVQRL RVFISHYTLL FQCNEDLLIQ KRKKLKKSSM AKLYKGLASQ CANAGQDASP
TAGPEAVRDS GIHSEEMLQP YPSTPSSGPA VTHLMPPMKK SQQQQSLMES MQPGKPSDWE
MEGRKHERPE SLLAPAQFCA AEQDVKALAG PLQAIPEMDF EPSPAEPPGH VERSLRAPAE
LLPDARGYVP AAYEEFEYGG EIFALPAPYD EEPFQAPALF ENCSPASSES SLDICFLRPV
SFAMEAERPE HPLQPLPKSA TSPASSSGAY KLEAAAQAQA QAHGKAKPLS RSLKEFPRAP
PPEGVAPRLY STRSSSGGRA PLKAERAAQP HGQAAAAAAR GAPRTFFPQQ RSQSEKQTYL
EEMHLEDATR FCPKDERESE QTSFSDQNPR QDQKGGFRSS FRKLFKKKGL FGWWPHTPRM
LLRDEARHGA RCNRKPGKGF SSL
//
