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Database: UniProt
Entry: A0A3Q2H8B0_HORSE
LinkDB: A0A3Q2H8B0_HORSE
Original site: A0A3Q2H8B0_HORSE 
ID   A0A3Q2H8B0_HORSE        Unreviewed;      1405 AA.
AC   A0A3Q2H8B0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 2.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Jumonji and AT-rich interaction domain containing 2 {ECO:0000313|Ensembl:ENSECAP00000029723.2};
GN   Name=JARID2 {ECO:0000313|Ensembl:ENSECAP00000029723.2,
GN   ECO:0000313|VGNC:VGNC:58735};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000029723.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000029723.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029723.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000029723.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029723.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   Ensembl; ENSECAT00000039880.3; ENSECAP00000029723.2; ENSECAG00000011721.4.
DR   VGNC; VGNC:58735; JARID2.
DR   GeneTree; ENSGT00940000159220; -.
DR   Proteomes; UP000002281; Chromosome 20.
DR   Bgee; ENSECAG00000011721; Expressed in inner cell mass and 23 other cell types or tissues.
DR   GO; GO:0035098; C:ESC/E(Z) complex; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR   GO; GO:0046976; F:histone H3K27 methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR   GO; GO:0061649; F:ubiquitin modification-dependent histone binding; IEA:Ensembl.
DR   GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0140718; P:facultative heterochromatin formation; IEA:Ensembl.
DR   GO; GO:0001889; P:liver development; IEA:Ensembl.
DR   GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:1902682; P:protein localization to pericentric heterochromatin; IEA:Ensembl.
DR   GO; GO:0060816; P:random inactivation of X chromosome; IEA:Ensembl.
DR   GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR   GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR   GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR   CDD; cd16870; ARID_JARD2; 1.
DR   Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR   Gene3D; 2.60.120.650; Cupin; 1.
DR   InterPro; IPR001606; ARID_dom.
DR   InterPro; IPR036431; ARID_dom_sf.
DR   InterPro; IPR003347; JmjC_dom.
DR   InterPro; IPR003349; JmjN.
DR   PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR   PANTHER; PTHR10694:SF113; PROTEIN JUMONJI; 1.
DR   Pfam; PF01388; ARID; 1.
DR   Pfam; PF02373; JmjC; 1.
DR   Pfam; PF02375; JmjN; 1.
DR   SMART; SM01014; ARID; 1.
DR   SMART; SM00501; BRIGHT; 1.
DR   SMART; SM00558; JmjC; 1.
DR   SMART; SM00545; JmjN; 1.
DR   SUPFAM; SSF46774; ARID-like; 1.
DR   SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR   PROSITE; PS51011; ARID; 1.
DR   PROSITE; PS51184; JMJC; 1.
DR   PROSITE; PS51183; JMJN; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          561..602
FT                   /note="JmjN"
FT                   /evidence="ECO:0000259|PROSITE:PS51183"
FT   DOMAIN          625..717
FT                   /note="ARID"
FT                   /evidence="ECO:0000259|PROSITE:PS51011"
FT   DOMAIN          888..1052
FT                   /note="JmjC"
FT                   /evidence="ECO:0000259|PROSITE:PS51184"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          43..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          357..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..194
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..264
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..321
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..399
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..449
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..505
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        533..547
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1405 AA;  155137 MW;  E19AAE7548206F47 CRC64;
     MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNAQKRQHGE GIAGSLKTVN
     GLLGNGQSKG LGPASEQSEN EKDDASQVSS TSNDVSSSDF EEGPSRKRPR LQAQRKFAQS
     QPNSPSTTPV KIVEPLLPPP ATQISDLSKR KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ
     DEEDVEEEDD ETEDVKTATN NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SSREKEPVQK
     HKSKEATPGK EKHSDHRADS RREQASATHP PAAPSPGSSA KGLAANHHHP PLHRSAQDLR
     KQVSKVNGVT RMSSLGTSAT SAKKMREVRP SPSKTVKYTA TVTKGTVTYT KAKRELVKET
     KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST GPAVNGLKVS GRLNPKSCTK
     EVGGRQLREG LRNSKRRLEE AHQAEKPQSP PKKMKGAAAC AEAPSRKAAA APALAPAPAD
     RALLSGPGKK DVPERSAERT RPKRATAGKS TPGRQAHGKP DGASCENRST SQSETLHKPH
     ETSARPEKGG GRAGWAAMDE IPVLRPSAKE FHDPLVYIES VRAQVEKYGM CRVIPPPDWR
     PECKLNDEMR FVTQIQHIHK LGRRWGPNVQ RLACIKKHLR SQGITMDELP LIGGCELDLA
     CFFRLINEMG GMQQVTDLKK WNKLADMLRI PKTAQDRLAK LQEAYCQYLL SYDSLSPEEH
     RRLEKEVLME KEILEKRKGP LEGHTEHDYN KFHPLPRFEP KNGLINGVAH RNGFRSKLKE
     VGQAQLKTGR RRLFAQEKEV VKEEEEDKGV LSDFHKCIYK GRSVSLTTFY RTARNIMNMC
     FSKEPAPAEI EQEYWRLVEE KDCHVAVHCG KVDTNTHGSG FPVGKSEPFS RHGWNLTVLP
     NNTGSILRHL GAVPGVTIPW LNIGMVFSTS CWSRDQNHLP YIDYLHTGAD CIWYCIPAEE
     ESKLEDVVHT LLQANGTPGL QMLESNVMIS PEVLCKEGIK VHRTVQQSGQ FVVCFPGSFV
     SKVCCGYSVS ETVHFATTQW TSMGFETAKE MKRRHIAKPF SMEKLLYQIA QAEAKKENGP
     TLSTISALLD ELRDTELRQR RQLFEAGLHS SARYGSHDGS STVADGKKKP RKWLQLETSE
     RRCQICQHLC YLSMVSPAPE LGPLPAARNS PRRGWERSKA LALCCPLLSL SHSHMAGRSG
     PPSVPLLCHP LSLGPAFPPS HPLARCWASL FLLPLTRCGG PTFFPCFQFP FQLCDQSHCP
     RGHWNLSLVK TNVSPQQHSA VSSLPASGRG CFSGAPMAPA EGSALASLSQ LVLLPLHLPT
     QLVRLPSFLV CSHSALQGLL TCQPVFSGLP APPSLGLITS ILPPLTLIAG QWQPEKPWLS
     GQLDWCSPLL CFFQLVSYLP LGQLP
//
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