ID A0A3Q2H8B0_HORSE Unreviewed; 1405 AA.
AC A0A3Q2H8B0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Jumonji and AT-rich interaction domain containing 2 {ECO:0000313|Ensembl:ENSECAP00000029723.2};
GN Name=JARID2 {ECO:0000313|Ensembl:ENSECAP00000029723.2,
GN ECO:0000313|VGNC:VGNC:58735};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000029723.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000029723.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029723.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000029723.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000029723.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000039880.3; ENSECAP00000029723.2; ENSECAG00000011721.4.
DR VGNC; VGNC:58735; JARID2.
DR GeneTree; ENSGT00940000159220; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000011721; Expressed in inner cell mass and 23 other cell types or tissues.
DR GO; GO:0035098; C:ESC/E(Z) complex; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0046976; F:histone H3K27 methyltransferase activity; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0061649; F:ubiquitin modification-dependent histone binding; IEA:Ensembl.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0140718; P:facultative heterochromatin formation; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:1902682; P:protein localization to pericentric heterochromatin; IEA:Ensembl.
DR GO; GO:0060816; P:random inactivation of X chromosome; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR GO; GO:0048538; P:thymus development; IEA:Ensembl.
DR CDD; cd16870; ARID_JARD2; 1.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF113; PROTEIN JUMONJI; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51011; ARID; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 561..602
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 625..717
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT DOMAIN 888..1052
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..194
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..505
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1405 AA; 155137 MW; E19AAE7548206F47 CRC64;
MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNAQKRQHGE GIAGSLKTVN
GLLGNGQSKG LGPASEQSEN EKDDASQVSS TSNDVSSSDF EEGPSRKRPR LQAQRKFAQS
QPNSPSTTPV KIVEPLLPPP ATQISDLSKR KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ
DEEDVEEEDD ETEDVKTATN NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SSREKEPVQK
HKSKEATPGK EKHSDHRADS RREQASATHP PAAPSPGSSA KGLAANHHHP PLHRSAQDLR
KQVSKVNGVT RMSSLGTSAT SAKKMREVRP SPSKTVKYTA TVTKGTVTYT KAKRELVKET
KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST GPAVNGLKVS GRLNPKSCTK
EVGGRQLREG LRNSKRRLEE AHQAEKPQSP PKKMKGAAAC AEAPSRKAAA APALAPAPAD
RALLSGPGKK DVPERSAERT RPKRATAGKS TPGRQAHGKP DGASCENRST SQSETLHKPH
ETSARPEKGG GRAGWAAMDE IPVLRPSAKE FHDPLVYIES VRAQVEKYGM CRVIPPPDWR
PECKLNDEMR FVTQIQHIHK LGRRWGPNVQ RLACIKKHLR SQGITMDELP LIGGCELDLA
CFFRLINEMG GMQQVTDLKK WNKLADMLRI PKTAQDRLAK LQEAYCQYLL SYDSLSPEEH
RRLEKEVLME KEILEKRKGP LEGHTEHDYN KFHPLPRFEP KNGLINGVAH RNGFRSKLKE
VGQAQLKTGR RRLFAQEKEV VKEEEEDKGV LSDFHKCIYK GRSVSLTTFY RTARNIMNMC
FSKEPAPAEI EQEYWRLVEE KDCHVAVHCG KVDTNTHGSG FPVGKSEPFS RHGWNLTVLP
NNTGSILRHL GAVPGVTIPW LNIGMVFSTS CWSRDQNHLP YIDYLHTGAD CIWYCIPAEE
ESKLEDVVHT LLQANGTPGL QMLESNVMIS PEVLCKEGIK VHRTVQQSGQ FVVCFPGSFV
SKVCCGYSVS ETVHFATTQW TSMGFETAKE MKRRHIAKPF SMEKLLYQIA QAEAKKENGP
TLSTISALLD ELRDTELRQR RQLFEAGLHS SARYGSHDGS STVADGKKKP RKWLQLETSE
RRCQICQHLC YLSMVSPAPE LGPLPAARNS PRRGWERSKA LALCCPLLSL SHSHMAGRSG
PPSVPLLCHP LSLGPAFPPS HPLARCWASL FLLPLTRCGG PTFFPCFQFP FQLCDQSHCP
RGHWNLSLVK TNVSPQQHSA VSSLPASGRG CFSGAPMAPA EGSALASLSQ LVLLPLHLPT
QLVRLPSFLV CSHSALQGLL TCQPVFSGLP APPSLGLITS ILPPLTLIAG QWQPEKPWLS
GQLDWCSPLL CFFQLVSYLP LGQLP
//