ID A0A3Q2H9H4_HORSE Unreviewed; 710 AA.
AC A0A3Q2H9H4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=RAP1 GTPase activating protein 2 {ECO:0000313|Ensembl:ENSECAP00000030729.3};
GN Name=RAP1GAP2 {ECO:0000313|Ensembl:ENSECAP00000030729.3,
GN ECO:0000313|VGNC:VGNC:22177};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000030729.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000030729.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000030729.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000030729.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000030729.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2H9H4; -.
DR Ensembl; ENSECAT00000033122.3; ENSECAP00000030729.3; ENSECAG00000020278.4.
DR VGNC; VGNC:22177; RAP1GAP2.
DR GeneTree; ENSGT00940000160935; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000020278; Expressed in oviduct epithelium and 21 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2H9H4; baseline.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 227..443
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 9..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 78139 MW; B3A489D2285C5CEE CRC64;
MPRKIWKQEL ANSSDVTLPD RPLSPPLTAP PTMKSAEFFE MLEKMQGIKL EEQKPGPQKN
KDDYIPYPSI DEIVEKGGPY PLIVLPQFGG YWIEDPENLG TPTSLGSSIC EEEEEDSLSP
NTFGYKLECR GEARAYRRHF LGKDHLNFYC TGSSLGNLLL SIKCEEAEGI EYLRIILRSK
VKTVHERIPL AGLSKLPSVP QIAKAFCDDA VGLKFNPVLY PKASQMIVSY DEHDVNNTFK
FGVIYQKARQ TLEEELFGNN EESPAFKEFL DLLGDTIMLQ DFKGFRGGLD VTHGQTGVES
VYTIFRDREI MFHVSTKLPF TEGDAQQLQR KRHIGNDIVA IIFQEENTPF VPDMIASNFL
HAYIVVQAEN AGTETPSYKV SVTAREDVPA FGPPLPSPPV FQKGPEFREF LLTKLTNAEN
ACCKSDKFAK LEDRTRAALL DNLHDELHAH TQAMLGLGPE EDKFENGGHG GFLESFKRAI
RVRSHSMETM VSSQKKQHSG GIPGSLSGGI SHNSVEVTKT TFSPPVAVAT AKNQSRSPIK
RRSGLFPRLH TGSEGQGDSR TRSDSASSNP KTPDGGHSSQ EIKSETSSNP SSPEICPNKE
KPFIKLKENG RANISRSSSS TSSFSSTAGE GEAMEECDSG SSQPSTTSPF KQEVFVYSQS
PSSESPSLGA AATPIIMSRS PTDVKSRNSP RSNLKFRFDK LSHAGSSAGH
//
