ID A0A3Q2HBJ0_HORSE Unreviewed; 747 AA.
AC A0A3Q2HBJ0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Pleckstrin homology domain containing M3 {ECO:0000313|Ensembl:ENSECAP00000030992.2};
GN Name=PLEKHM3 {ECO:0000313|Ensembl:ENSECAP00000030992.2,
GN ECO:0000313|VGNC:VGNC:21576};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000030992.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000030992.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000030992.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000030992.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000030992.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2HBJ0; -.
DR Ensembl; ENSECAT00000041570.3; ENSECAP00000030992.2; ENSECAG00000008108.4.
DR VGNC; VGNC:21576; PLEKHM3.
DR GeneTree; ENSGT00940000159743; -.
DR Proteomes; UP000002281; Chromosome 18.
DR Bgee; ENSECAG00000008108; Expressed in spinal cord and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HBJ0; baseline.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR025258; RH_dom.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12326:SF10; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF13901; RH_dom; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 360..455
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 747 AA; 84677 MW; 3413DB379FECFEEB CRC64;
MEALEVDDIS PALEVTEDFF STFDNKLEKV VQQAEVYGIQ EVPELVGQEV FSNVTDNGAI
RNVASLGKGG MIWDSCKSRL LETKVQNVFP AKEQFMVQKG TTPDNLSWVE QKEASTFNFF
NICQRRRDRP RSVNDLLDET STFKPGHARS RSDITQVDWR VVLKSTPLQQ QRQQPSLQGP
YFTRPSCLSP SPNKVEDAQG NTEHKQAFPN ILKKGYLEIR KDHDSYWQSC YAELSPYSLC
FYNLDSSGNQ NLHDTYQLSH FQSISVLGNL EARLVDTVLY DNTQLQLKAE SPWEALDWGQ
KLWEVTHAAV PGYVGRQDEL ANSPGLGPHV DCTQRHYLQQ KSSELLLLSP VLGGPRQHQN
ILKSGTLYRL TIQNNWKAFT FVLSQACLMA FQPGKLDEDP LLSYNVDVCL AVQTDNLDDC
DSCFQVIFPQ DVLRLRAETR QRAQEWMEAL KTAANAARSS EQNLQVTLRN KPMDLVGGLG
LRKSQRQSVT TSFLSILTTL SLERGLTAQS FKCAGCQRPI GLSNGKAKVC SYSGWYYCSS
CHVDDSFLIP ARIVHNWDTS KYKVSKQAKE FLEYVYEEPL IDIQQENPLL YQHAEPLATV
VRLRQRLTSL RAYLFSCRAA VAEDLRRRIF PREYLLQQIH LYSLSDLQQV IEGKLAPFLG
KVIKFAASHV YSCSLCSQKG FICEICNNGE ILYPFEDIST SSLSLFCCFF YILHVGSRHN
MVDEPCVCLH LGSKPANPGL PKQSRRT
//