ID A0A3Q2HBJ8_HORSE Unreviewed; 328 AA.
AC A0A3Q2HBJ8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Cyclin dependent kinase inhibitor 1C {ECO:0000313|Ensembl:ENSECAP00000030685.1};
GN Name=CDKN1C {ECO:0000313|Ensembl:ENSECAP00000030685.1};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000030685.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000030685.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000030685.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000030685.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000030685.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDI family. {ECO:0000256|ARBA:ARBA00006726}.
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DR AlphaFoldDB; A0A3Q2HBJ8; -.
DR STRING; 9796.ENSECAP00000030685; -.
DR PaxDb; 9796-ENSECAP00000030685; -.
DR Ensembl; ENSECAT00000052438.2; ENSECAP00000030685.1; ENSECAG00000031389.2.
DR GeneTree; ENSGT00940000162677; -.
DR InParanoid; A0A3Q2HBJ8; -.
DR OMA; QENRTDK; -.
DR Proteomes; UP000002281; Chromosome 12.
DR Bgee; ENSECAG00000031389; Expressed in trophoblast and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0042326; P:negative regulation of phosphorylation; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR Gene3D; 4.10.365.10; p27; 1.
DR InterPro; IPR003175; CDI_dom.
DR InterPro; IPR044898; CDI_dom_sf.
DR PANTHER; PTHR10265; CYCLIN-DEPENDENT KINASE INHIBITOR 1; 1.
DR PANTHER; PTHR10265:SF44; CYCLIN-DEPENDENT KINASE INHIBITOR 1C; 1.
DR Pfam; PF02234; CDI; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein kinase inhibitor {ECO:0000256|ARBA:ARBA00023013};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 99..149
FT /note="Cyclin-dependent kinase inhibitor"
FT /evidence="ECO:0000259|Pfam:PF02234"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..192
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 34089 MW; 79AED5649811437F CRC64;
MLIAAGPARG GGGVGPSRIK GRARTGRSTG QVLCAWCVPA RAATKQTRTG TEGARPSAGR
HSEREAGAIH SRTTSALAME RLVARRTYPL FARTSACRSL FGPVDHEELS RELRIRLAEL
SAEDQRRWDY NFQQDMPLRG PGRLQWTEVD SDSVPAFYRE TVQVGRCRLL LAPRPRPDGA
ANSPPPGPPA DEPLDGLGEA PEPPSSGAAV APTPAPAVGP QESDEEEAIP PPRSQEPLAE
PLHSGISGRP APGTAAAAAT AAAAATTAAA GGAAMKKLPG PLISDFFAKR KRPAPDAKAS
NEVPAGCAAA GAAPTVGSAE QTPRKRLR
//
