ID A0A3Q2HDS1_HORSE Unreviewed; 352 AA.
AC A0A3Q2HDS1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DnaJ homolog subfamily B member 14 {ECO:0000256|ARBA:ARBA00039610};
GN Name=DNAJB14 {ECO:0000313|Ensembl:ENSECAP00000032465.2,
GN ECO:0000313|VGNC:VGNC:49046};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000032465.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000032465.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000032465.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000032465.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000032465.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.
CC {ECO:0000256|ARBA:ARBA00038010}.
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DR AlphaFoldDB; A0A3Q2HDS1; -.
DR STRING; 9796.ENSECAP00000032465; -.
DR PaxDb; 9796-ENSECAP00000032465; -.
DR Ensembl; ENSECAT00000046085.2; ENSECAP00000032465.2; ENSECAG00000008379.4.
DR VGNC; VGNC:49046; DNAJB14.
DR GeneTree; ENSGT00940000157887; -.
DR InParanoid; A0A3Q2HDS1; -.
DR OMA; RFCHVEL; -.
DR OrthoDB; 2785358at2759; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000008379; Expressed in spinal cord and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HDS1; baseline.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0030544; F:Hsp70 protein binding; IBA:GO_Central.
DR GO; GO:0071218; P:cellular response to misfolded protein; IBA:GO_Central.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR015399; DUF1977_DnaJ-like.
DR InterPro; IPR036869; J_dom_sf.
DR PANTHER; PTHR43908; AT29763P-RELATED; 1.
DR PANTHER; PTHR43908:SF4; DNAJ HOMOLOG SUBFAMILY B MEMBER 14; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF09320; DUF1977; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 108..172
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 56..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 39199 MW; ADAFBA1164AA3665 CRC64;
MEGNRDEAEK CVEIAREALN AGDRERAQRF LHKAQKLYPL PAARALLEII MKNGSTAGSS
PHCRKPATSG DQGRPNCTKD STTAGGEGGK GYTKDQVDGV LSINKCKNYY EVLGVTKDAG
DEDLKKAYRK LALKFHPDKN HAPGATDAFK KIGNAYAILS NPEKRKQYDL TGNEEQACNH
QNNGRFNFHR GCEADITPED LFNIFFGGGF PSGSVHSFSN GRAGYSHQHQ HRHSGHEREE
ERGDGGFSVF IQLMPIIVLI LVSLLSQLMV SSPPYSLYPR SGSGQTIKMQ TENLGVVYYV
NKDFKNEYKG VLLQKVEKSV EEDYVTNIRN NCWKERQQNP EKSPALLPLS IF
//
