ID A0A3Q2HDW6_HORSE Unreviewed; 1856 AA.
AC A0A3Q2HDW6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=SET binding factor 2 {ECO:0000313|Ensembl:ENSECAP00000032636.2};
GN Name=SBF2 {ECO:0000313|Ensembl:ENSECAP00000032636.2,
GN ECO:0000313|VGNC:VGNC:22706};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000032636.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000032636.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000032636.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000032636.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000032636.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR Ensembl; ENSECAT00000059684.2; ENSECAP00000032636.2; ENSECAG00000023537.5.
DR VGNC; VGNC:22706; SBF2.
DR GeneTree; ENSGT00940000155385; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000023537; Expressed in spinal cord and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HDW6; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR CDD; cd14589; PTP-MTMR13; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF4; MYOTUBULARIN-RELATED PROTEIN 13; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 15..434
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1115..1591
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1750..1854
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1681..1701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1856 AA; 208882 MW; 877B6C27B8459A94 CRC64;
MSVLLTCFYE SVGWGLPVVL VLCLKGSGAG LGKIIQRFPQ KDWDDTPFPQ GIELFCQPSG
WQLSRERKQP TFFVVVLTDI DSDRHYCSCL TFYEAEINLQ GTKKEEIEGE VEVTGLIQPA
EVFAPKSLVL VSRLDYPDVF RACLGLIYTV YVDSLNVSLE SLIANLCACL VPAAGGSQKL
FSLGAGDRQL IQTPLHDSLP VTGTSVALLF QQLGIQNVLS LFCAVLTENK VLFHSASFQR
LSDACRALES LMFPLKYSYP YIPILPAQLL EVLSSPTPFI IGVHSIFKTD VHELLDVIIA
DLDGGTIKIP ECIHLSSLPE PLLQQTQAAL SLILHPDLEV ADHAFPPPRT ALSHSKMLDK
EVRAVFLRLF AQLFQGYRSC LQLIRIHAEP VIHFHKTAFL GQRGLVENDF LIKVLNGMAF
AGFVSERGPP YRSCDLFDEL VAFEVERIKV EENNPLKMIK HVRELAEQLF KNENPNPHMA
FQKVPRPTEG SHLRVHILPF PKINETRVQE LIQENLAKNQ NAPPALRVEK KWVVPAGPPV
VSIMDKVTTV FNSAQRLEVV RNCISFIFEN KTLETEKTLP AALRALKGKA ARQCLTDELG
LHVQQNRAIL DHQQFDYIIR MMNCTLQDCS SLEEYNIAAA LLPLTSAFYR KLAPGVSQFA
YTCVQDHPIW TNQQFWETTF YNAVQEQVRS LYLSAKEDNH ALHLKQKDKL PDDQYQEKTA
MDLAAEQLRL WPTLSKSTQQ ELVQREESTV FSQAIHFANL MVNLLVPLDT SKNKLLRASA
PGDWESGSNS IVTNSIAGSV AESYDTESGF EDSENNDIAN SVVRFITRFI DKVCTESGVT
QDHIKSLHCM IPGIVAMHIE SLEAVHRESR RLPPIQKPKI LRPALLPGEE VVCEGLRVLL
DPDGREEATG GLLGGPQLLP AEGALFLTTY RILFRGTPHD QLVGEQTVVR SFPIASITKE
KKITMQNQLQ QNMQEGLQIT SASFQLIKVA FDEEVSPEVV EIFKKQLMKF RYPQSIFTTF
AFAAGQTTPQ IILPKQKEKN TSFRTFSKTI VKGAKRAGKM TIGRQYLLKR RTGTIVEERV
NRPGWNEEDD VSVSDDSELP TSTTLKASEK STMEQLVEKA CFRDYQRLGL GTISGSSSRS
KPEYFRITAS NRMYSLCRSY PGLLVVPQAV QDSSLPRVAR CYRHNRLPVV CWKNSRSSTL
LLRAGGFHGK GVVGLFKSQN SPQAAPTSSL ESSSSIEQEK YLQALLNAVS VHQKLSGNNT
LTVRPALALS PGVWASLRSS TRLISSPTSF IDVGARLAGK DHSASFSNSA YLQNQLLKRQ
AALYIFGEKS QLRNFKLEFA LNCEFVPVEF HDIRQVKASF KKLMRACVPS TIPTDSEVTF
LKALGDSEWF PQLHRIMQLA VVVSEILENG SSVLVCLEEG WDVTAQVTSL VQLLSDPFYR
TLEGFRMLIE KEWLSFGHKF SQRSSLTLNS QGSGFAPVFL QFLDCVHQVH TQYPTEFEFN
LYYLKFLAFH YVSNRFKTFL LDSDYERLEH GTLFDDKGDK HAKKGICIWE CIDRMHKRSP
IFFNYLYSPV EIEALKPSVN VSSLKKWDYY IEETLSTGPS YDWMMLSPKH FSSEDSELAG
GAGPRSQRKT VWPCYDDVRC AQPDALTSLF SEIERLEHKL NQTPEKWQQL WERVTVDLKE
EPRADRPQRH PSGSPGIVST NLPSYQKRSL LHLPDSSVGD EQNASVSPSN GVDRRAATLY
SQYTSKNDEN RSFEGTLYKR GALLKGWKPR WFVLDVTKHQ LRYYDSGEDT SCKGHIDLAE
VEMVIPAGPS MGAPKHTSDK AFFDLKTSKR VYNFCAQDGQ SAQQWMDRIQ SCISDA
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