ID A0A3Q2HEP7_HORSE Unreviewed; 1124 AA.
AC A0A3Q2HEP7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ubiquitin specific peptidase like 1 {ECO:0000313|Ensembl:ENSECAP00000032067.1};
GN Name=USPL1 {ECO:0000313|Ensembl:ENSECAP00000032067.1,
GN ECO:0000313|VGNC:VGNC:24857};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000032067.1, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000032067.1, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000032067.1,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000032067.1}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000032067.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005601178.1; XM_005601121.2.
DR AlphaFoldDB; A0A3Q2HEP7; -.
DR STRING; 9796.ENSECAP00000032067; -.
DR PaxDb; 9796-ENSECAP00000032067; -.
DR Ensembl; ENSECAT00000057924.3; ENSECAP00000032067.1; ENSECAG00000011889.4.
DR VGNC; VGNC:24857; USPL1.
DR GeneTree; ENSGT00390000002316; -.
DR InParanoid; A0A3Q2HEP7; -.
DR OMA; NANALCW; -.
DR OrthoDB; 3740838at2759; -.
DR Proteomes; UP000002281; Chromosome 17.
DR Bgee; ENSECAG00000011889; Expressed in trophectoderm and 23 other cell types or tissues.
DR ExpressionAtlas; A0A3Q2HEP7; baseline.
DR GO; GO:0015030; C:Cajal body; IBA:GO_Central.
DR GO; GO:0016929; F:deSUMOylase activity; IEA:Ensembl.
DR GO; GO:0032183; F:SUMO binding; IBA:GO_Central.
DR GO; GO:0030576; P:Cajal body organization; IBA:GO_Central.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0016926; P:protein desumoylation; IBA:GO_Central.
DR GO; GO:0009301; P:snRNA transcription; IEA:Ensembl.
DR InterPro; IPR029388; DUF4650.
DR InterPro; IPR028890; Peptidase_C98.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR033505; USPL1.
DR PANTHER; PTHR15294; RETINOVIN-RELATED; 1.
DR PANTHER; PTHR15294:SF3; SUMO-SPECIFIC ISOPEPTIDASE USPL1; 1.
DR Pfam; PF15509; DUF4650; 1.
DR Pfam; PF15499; Peptidase_C98; 2.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 229..528
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 821..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1124 AA; 123513 MW; 28E508B026E57AE4 CRC64;
MMDSPKIGNG LPVIGPGTDI GISSLHVVGY LGKNYDSANV PSDGYCPACR EKGKLKALKT
YRISFQESVF LCEDLQCIYP LGSKSLNNLI SPDLEDCHTT NKPQKRKLLE TNYKDSPVVA
CSKKTKSRVV IDGEQVLNSK QNEAACDETS SDLPDVLHSG QQKPGRTADS LEQGEILEAN
IVDVAAEEDP ATIDVSRTGG TSPQNEGCTS GLEMPLENRC TSLCQTLCVQ WKNAYALCWL
DCILSALVHL EGLKNTVTDL CSKEESVFCR LFTKYDQANK LLHTSQLDGV EDGDCKKLTS
EIFAKIETCL NEVRDEIFIR LQPQLRCTLG DMESPVFAFP LLLKIEPHIE KLFTYSFSWN
FECSQCGHKY QNRCMKNLVT FTNVIPEWHP LNAAHFGPCN SCNNKSQIRK MVLEKFWCFT
YYLSCLTKAV WALDAKENSK RVSPIFMVHF VEGLPRDDLQ HYSFHFEGCL YQITSVIQYQ
ANNHFITWIL DADGSWLECD DLKGSCSERH EKFEVSVSEI HIVIWERKTS QVTNKASACP
ALKKANDEHA VGDEKQASPA LCSLGHAASA ETSSGTHPTN MSVALNTLAQ DEAVAHENNL
LSGPEDLVDN ILPLTLEEIQ VNPEGFLLED KPVAENAGVI KTNTLQSQES LTASLVSAPC
KEKLTQDQFV DLSFPSQFVN TNVQLVQLNT EDTVITKSVN NVHATDAMQE VKSVEFEGTV
VLEKDAPLKQ FLSPKTEKLK PEQLVTSQVS NLKKEETAAF SQTITAKSLQ SPSLKENQKK
PFVGSWVKGL LSKGASFMPP CVSAHNRNTI TDLQPSVKGA SNFGGFKTKG IKQKANRTSK
KAHKCSSKPP PVSNPPPSLP SGSPASQLHA SVTAHSEVLK KCENTSSGAH LNHSSHGSEG
GVSSANHGDL VEGQIHKLRL KLLKKLKAKK KKLAALMSSP QNGTHPSENL EHGSHCGSPN
DCGSIEDLLK ELQDQIDIAD NKSGGTTAPS ISSYSSQTHE EILAELLSPT TIVSAELSEN
GEADFRYLEM GDNHIPAPVP SDLNDTPQNA HLRQDHNYCS PTKKTQSEVQ PDSFINNAGV
RTLNLESSMK TDIFDEFFST SALNSLANDT LDLPHFDEYL FESC
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